미국 Accegen은 생명과학 연구와 의약품 개발을 지원하기 위해 다양한 세포주와 생물학적 제품을 제공하는 바이오 제품 제조 기업입니다.

제품 설명

JIMT-1

제품 번호

ABC-TC504S

제품 특징

JIMT-1 is a breast cancer cell line established from a 62-year-old woman’s pleural effusion with ductal breast cancer in 2003. These cells carry an amplified HER-2 oncogene, making them insensitive to HER-2-inhibiting drugs. JIMT-1 cells lack estrogen and progesterone receptors and overexpress HER-2 mRNA and protein. JIMT-1 cells are of epithelial progenitor cell origin, confirmed by positive immunohistochemical staining for cytokeratins 5/14 and 8/18. They grow as an adherent monolayer and can therefore be culture in DMEM with 10% FBS.

Why choose JIMT-1 from AcceGen?

JIMT-1 cell line from AcceGen possesses several key features. Firstly, it undergoes routine authentication through STR profiling, ensuring the consistency and reliability of its genetic identity. Secondly, the cells are maintained under sterile conditions and regularly tested to confirm the absence of bacterial, fungal, and mycoplasma contamination. This ensures the integrity of experiments and prevents potential cross-contamination. Lastly, the cell line is handled professionally, with careful cryopreservation techniques employed to maintain high viability. These features contribute to the quality and reliability of JIMT-1 cells for use in various research applications.

The JIMT-1 breast cancer cell line offers valuable applications in cancer research and drug development. It can form xenograft tumors in mice, allowing researchers to study the effectiveness of drugs or inhibitors both in vitro and in vivo. For instance, JIMT-1 cells have been extensively used to test HER-2-targeting drugs and small molecule tyrosine kinase inhibitors aimed at inhibiting the HER-2 pathway. Additionally, JIMT-1 cells can be utilized for genomic screening to identify key genes involved in cell proliferation and tumor growth. These applications make JIMT-1 a valuable tool for understanding breast cancer biology, exploring drug resistance mechanisms, and developing targeted therapies.

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PRODUCTS

• Primary Cells
• Tumor Cell Lines
• MicroRNA Agomir/Antagomir
• Stem Cells
• Immortalized Cell Lines
• Transfected Stable Cell Lines
• Nucleic Acid Kits