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제품 설명

Immortalized Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells

제품 번호

ABC-TC0524

제품 특징

Description

Human Myeloma Cell Line KMS-11 is derived from pleural effusion of a 67-year-old Japanese female patient with multiple myeloma. These cells are B-cell type and exhibit small round morphology with some multinucleate forms. They secrete immunoglobulin κ (IgG κ) and show positive reaction with PCA-1. KMS-11 has chromosomal abnormalities. The cell line carries a FGFR3 gene mutation (p.Tyr373Cys) and expresses high levels of tumor markers. In terms of tumorigenicity, KMS-11 does not show tumor formation in subcutaneous nude mouse models. They display unique growth properties, including both adherent and suspension growth, making them a valuable model for studying tumor cell heterogeneity and microenvironment adaptation. KMS-11 is widely used in studies on multiple myeloma, immunoglobulin synthesis, and drug screening.

Citation

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Application

• • KMS-11 can be used to map proliferation-related signaling pathways in myeloma and identify inhibitors for myeloma cell growth and survival.For example, Interleukin-6 (IL-6) was identified as one of the most important growth factors for myeloma cells, inducing enhanced growth in KMS-11 cells, accompanied by down-regulation of protein kinase C (PKC) activity. JAK inhibitor, which can affect the IL-6/JAK signal transduction, induced cell death of the KMS-11 cells and inhibited tumor growth in a KMS-11 xenograft mouse model. For drug development, ginseng was observed as a candidate for the treatment of myeloma. IH901, a derivative of ginseng,triggered several biochemical events, including the cleavage of poly (ADP-ribose) polymerase (PARP), internucleosomal DNA fragmentation, the activation of caspase-3, the down-regulation of FGFR3, the inhibition of ERK activity, and the apoptosis in KMS-11 cell line.

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PRODUCTS

• Primary Cells
• Tumor Cell Lines
• MicroRNA Agomir/Antagomir
• Stem Cells
• Immortalized Cell Lines
• Transfected Stable Cell Lines
• Nucleic Acid Kits

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