Rapid Alpha-Pseudovirus for Influenza Virus

Built-to-order alpha-pseudovirus for Influenza viruses (IAV) with the Hemagglutinin (HA), Neuraminidase (NA), Nucleoprotein (NP), Matrix (M1), and Ion Channel (M2).

Applications:

• IAV pseudovirus transduction of target cells for viral entry and functional studies
• Rapid Anti-IAV drug screening
• Rapid Anti-IAV neutralizing antibody screening
• Determination of seroconversion and seroprotection

A novel rapid hybrid alpha-pseudovirus for Influenza virus (Ha-IAV) and other Orthomyxoviridae viruses are now available at Virongy. Ha-IAV particles are pseudoviruses assembled from the structural proteins of the Influenza virus: Hemagglutinin (HA), Neuraminidase (NA), Nucleoprotein (NP), Matrix (M1), and the Ion Channel (M2). They also encapsulate an alphaviral vector for reporter gene expression. The alpha-pseudoviruses are single-cycle viruses with self-amplifying RNA for rapid quantification of neutralizing antibodies, seroconversion, seroprotection, and entry-inhibiting drugs. These pseudoviruses are BSL-2 safe and ready to use for studying viral entry. Furthermore, we assist our customers in constructing Ha-IAV pseudoviruses at any scale.

• Seroconversion: The process by which a person develops detectable antibodies in the blood in response to an infection or vaccination. It marks the point at which the immune system begins to produce a measurable immune response, indicating that the body has recognized the pathogen.

• Seroprotection: The level of antibodies in the bloodstream that is considered sufficient to protect against infection. It is often used as a measure of the effectiveness of a vaccine or immune response, indicating that a person has enough antibodies to prevent illness if exposed to the pathogen. For influenza, a serum neutralization titer of 1:40 or greater at a 50% inhibition of viral infectivity is commonly considered a protected titer

Available Strains: 

• Influenza A/Brevig-Mission/1/1918(H1N1)
• Influenza A/California/04/2009(H1N1)
• Influenza A/Victoria/4897/2022 (H1N1)
• Influenza A/Darwin/9/2021(H3N2)
• Influenza A/Thailand/NBL1/2006(H5N1)
• Influenza A/Texas/37/2024 (H5N1)
• Influenza A/Jiangsu/1/2013(H7N9)

Need a strain not listed here? Ask us about a custom alpha-pseudovirus for your project. For inquiries, please reach out to us via email: info@virongy.com

To enhance your pseudovirus entry, inquire about receiving a complimentary sample of our proprietary Infectin, which significantly enhances productive viral infection in various host cells, thereby boosting the viral infection rate by 3- to 20-fold.

Background: