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제품 설명
Pseudoviral Particles (Andes Orthohantavirus)
제품 특징
PsLv-ANDV-01 | |
Name | Andes orthohantavirus (ANDV) Pseudoviral Particles, Lentivirus-based |
Description | This ANDV pseudovirus is replication-deficient Lentivirus pseudotyped with the envelope glycoproteins of ANDV |
Applications | Our pseudoviral particles carry dual reporter genes-firefly luciferase (FLuc) and GFP-enabling versatile detection. Upon infecting target cells, the Pseudoviral Particles (PP) mediate FLuc expression, allowing quantitative assessment of infectivity via luciferase activity. Additionally, GFP serves as a fluorescent marker for visual confirmation and downstream analysis of transduced cells. |
Size | 5ml (for one multi-well plate). Pseudoviral particles per mL > 4.7E+07 |
Storage | -70oC. Shipped on dry ice. |
Note | Amenable to HTS format (96-well, 384-well and 1536-well format). |
For Downloading | ==>> DATA SHEET ==>> GHS SDS |
Andes orthohantavirus (ANDV) is an enveloped, negative-sense, three-segmented RNA virus belonging to the family Hantaviridae and is the principal cause of Hantavirus Cardiopulmonary Syndrome (HCPS) in South America. Among hantaviruses, ANDV is unique in its documented ability to spread from person to person. Viral entry is mediated by the envelope Gn/Gc glycoprotein complex, which binds host-cell receptors and triggers membrane fusion, making these glycoproteins the primary targets of neutralizing antibodies and vaccine development.
eEnzyme's Andes Orthohantavirus Pseudoviral Particles are replication-deficient lentiviral particles pseudotyped with the ANDV Gn/Gc glycoproteins and engineered to express a firefly luciferase reporter for quantitative measurement of viral entry. These pseudoviral particles provide a safe and convenient BSL-2-compatible platform for investigating hantavirus entry, evaluating neutralizing antibodies, screening antiviral compounds, and supporting vaccine development without handling infectious ANDV. Pseudovirus-based assays are widely used for quantitative, high-throughput studies of Andes virus entry and neutralization.
Andes orthohantavirus pseudoviral particles faithfully reproduce the Gn/Gc-dependent viral entry process while remaining replication incompetent. They provide a robust experimental system for studying viral entry mechanisms, evaluating neutralizing antibodies, characterizing envelope glycoprotein variants, and screening antiviral therapeutics under standard BSL-2 laboratory conditions. Consequently, ANDV pseudovirus assays have become valuable tools for hantavirus research, vaccine development, and therapeutic discovery.
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