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제품 설명

Goat anti-Mouse IgD, Antiserum, 1 mL

제품 번호

2057001

제품 특징

Description

Immunoglobulin D activator for B-cells. Preservative-free for in vivo application.

Immunoglobulin D (IgD) is an antibody isotype that is found primarily on mature B-cells as part of the B-cell receptor (BCR) complex. Clustering of the BCR due to antigen binding leads to activation of B-cells that can result in a number of outcomes including proliferation, differentiation, and tolerance.

The ability to activate B-lymphocytes using polyclonal antisera recognizing anti-IgD is useful for the study of B-cell function (Finkelman, et al., 1985; Nguyen, et al., 2014). Anti-IgD is particularly suited for this application because soluble IgD is present in extremely low levels in serum (<0.25% of total immunoglobulin) and will not interfere with B-cell activation in a whole blood-based or in vivo setting. (In contrast, high levels of circulating IgM will typically block B-cell activation by anti-IgM in whole blood.) Such a methodology can be used to rapidly test the efficacy of B-cell inhibitory agents in a cellular, ex vivo, or in vivo context (Coffey, et al., 2012).

Data/Specifications:

• Format: 1 ml per vial
• Host: Goat
• Reactivity: Mouse immunoglobulin Cδ chain
• Buffer: None
• Preservative: Preservative-free for in vivo application, 0.2 μm sterile-filtered
• Storage: Short term at 2- 8°C. For long term storage, -80°C is recommended. Avoid multiple freeze- thaw cycles. Should be kept sterile. Can be re-filtered if necessary.