Synbio Technologies는 혁신적인 합성 생물학 솔루션을 제공하여 생명과학 연구 및 개발을 지원하는 기업입니다.
CpG ODNs
CpG ODNs are short, synthetic, single-stranded DNA molecules containing unmethylated oligo deoxynucleotides (ODNs). Pre-clinical studies and trials have demonstrated that CpG ODNs can significantly improve vaccine-specific antibody responses.
CpG ODNs possess a partial or complete phosphorothioate (PS) backbone, as opposed to the natural phosphodiester (PO) backbone found in genomic bacterial DNA. Three major classes of stimulatory CpG ODNs have been identified. These classes are based on structural characteristics and activity on human peripheral blood mononuclear cells (PBMCs), in particular B cells and plasmacytoid dendritic cells (pDCs). These three classes are Class A (Type D), Class B (Type K) and Class C.
Synbio Technologies offer these three types of CpG ODNs. Each class boasts unique structural characteristics and immune effects suited for different applications.
Highlights
High Purity ＞95% purity
Low Endotoxin <5 EU/mg endotoxin level
Various Unit Size Sizing from mg to g
Cost-Effective Competitive prices and Customized Synthesis
Service Details
Class A
CpG ODNs are characterized by a PO central, CpG-containing palindromic motif and a PS-modified 3’ poly-G string. They induce high IFN-α production from pDCs but are weak stimulators of TLR9-dependent NF-κB signaling and pro-inflammatory cytokine (e.g. IL-6) production.
Class B
CpG ODNs are linear and fully modified with phosphorothioates. They possess strong immunostimulatory activity on B cells but fail to activate plasmacytoid dendritic cells.
Class C
CpG ODNs combine features of both class A and B, making them highly versatile as they activate both plasmacytoid dendritic cells and B cells.
Name | Cat（#） | Species | Size/Tube |
CpG ODN 1585 | SOC-A1585 | Mouse | 1mg |
CpG ODN 2216 | SOC-A2216 | Human Preferred | 1mg |
CpG ODN 2336 | SOC-A2336 | Human Preferred | 1mg |
CpG ODN 1668 | SOC-B1668 | Mouse | 1mg |
CpG ODN 1826 | SOC-B1826 | Mouse | 1mg |
CpG ODN 2006/7909 | SOC-B2006 | Human Preferred | 1mg |
CpG ODN 2007 | SOC-B2007 | Bovine/Porcine | 1mg |
CpG ODN BW006/684 | SOC-BW006 | Human&Mouse | 1mg |
CpG ODN D-SL01 | SOC-BDSL01 | Multispecies | 1mg |
CpG ODN 2395 | SOC-C2395 | Human/Mouse | 1mg |
CpG ODN M362 | SOC-CM362 | Human/Mouse | 1mg |
CpG ODN D-SL03 | SOC-CDSL03 | Multispecies | 1mg |
CpG ODN 10101 | SOC-10101 | Human&Mouse | 1mg |
CpG ODN IMT504 | SOC-IMT504 | Human&Mouse | 1mg |
CpG ODN 1982 | SOC-1982 | Human&Mouse | 1mg |
CpG ODN 2088 | SOC-2088 | Human&Mouse | 1mg |
CpG ODN 21158 | SOC-21158 | Human&Mouse | 1mg |
CpG ODN 4084-F | SOC-4084-F | Human&Mouse | 1mg |
CpG ODN 5328 | SOC-5328 | Human&Mouse | 1mg |
CpG ODN BW001 | SOC-BW001 | Human&Mouse | 1mg |
CpG ODN INH-1 | SOC-INH-1 | Human&Mouse | 1mg |
CpG ODN M326 | SOC-M326 | Human&Mouse | 1mg |
CpG ODN TTAGGG | SOC-TTAGGG | Human&Mouse | 1mg |
Deliverables
Lyophilized DNA Oligo Powder
Certificate of Analysis (COA)
Yield: 1mg
FAQs
ddH2 and saline
Can 1 mg of CpG be dispensed into 100 ug per tube?
The default shipping form is 1 mg/tube, not divided. Upon receipt, customers can dissolve and freeze the tubes, and take one tube at a time.
It is recommended to store your CpGs at -20℃
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