본문 바로가기 주메뉴 바로가기

제품소개

Home

제품상세페이지

Broadpharm

[Broadpharm] DBCO-PEG4-NHS ester

Cat-No. BP-22288



Broadpharm는 생화학 제품과 연구용 화학 시약을 제공하는 글로벌 바이오 및 제약 회사입니다.




제품 설명 


DBCO-PEG4-NHS ester



제품 번호

 

BP-22288

 


제품 특징


DBCO-PEG4-NHS Ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Please contact us for GMP-grade inquiries.


  • Catalog:

     

    BP-22288

  • Name:

     

    DBCO-PEG4-NHS ester

  • Formula:

     

    C34H39N3O10

  • MW:

     

    649.7

  • CAS:

     

    1427004-19-0

  • Purity:

     

    98%

  • Ships Within:

     

    24 Hours

  • Storage Condition:

     

    -20°C

  • Solubility:

     

    DMSO, DCM, DMF

  • Shipping:

     

    Ambient Temperature

  • Availability:

     

    In Stock

  • NMR:

     

    View

  • SDS:

     

    View


Product Citations

  1. Abdessamad Tahiri-Alaoui, Prameen Kalikavunkal, Atherton MUTOMBWERA, William James. Diagnostic device. (WO2024149986A1)
    https://patents.google.com/patent/WO2024149986A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=15
  2. Aphrham, S., Verheijden, M., & Huskens, J. (2025). Material-Selective Deposition of Reactive Group-Functionalized Poly-l-lysine for DNA Sensing at Optical Waveguides. ACS omega, 10(47), 57674-57683.
    https://pubs.acs.org/doi/full/10.1021/acsomega.5c09098
  3. Bian, Y. (2025). Precision Adjuvant Design Enabling Tailored Nanoparticle Immunization Platforms for Oxycodone and Other Substance Abuse Vaccines.
    https://vtechworks.lib.vt.edu/items/14ef956b-0f57-463d-a685-bb9a4877b076
  4. Dong, Y., You, F., Zhang, Y., Sun, H., Cheng, R., Zhao, S., ... & Zhong, Z. (2024). CD7 Nanobody-Based Immuno-Nanotoxin for Targeted Treatment of T-Cell Acute Lymphoblastic Leukemia. ACS Applied Nano Materials, 7(7), 7195-7202.
    https://doi.org/10.1021/acsanm.3c06253
  5. https://pubs.acs.org/doi/full/10.1021/acsomega.5c09098
    Click Chemistry
  6. Krishnan, M. A., Alimi, O. A., Pan, T., Kuss, M., Korade, Z., Hu, G., ... & Duan, B. (2024). Engineering Neurotoxin-Functionalized Exosomes for Targeted Delivery to the Peripheral Nervous System. Pharmaceutics, 16(1), 102.
    https://www.mdpi.com/1999-4923/16/1/102
  7. Li, Y., Awasthi, S., Liu, P., Protopopova, A., & Mayer, M. (2025). Selective and Controllable Trapping of Single Proteins in Nanopores using Reversible Covalent Bonds. bioRxiv, 2025-09.
    https://www.biorxiv.org/content/10.1101/2025.09.11.675362v1.full
  8. Marzolini, N., Brysgel, T. V., Essien, E. O., Rahman, R. J., Wu, J., Majumder, A., ... & Brenner, J. S. (2025). Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity. bioRxiv, 2025-07.
    https://www.biorxiv.org/content/10.1101/2025.07.09.663747v1.full
  9. Mauser, Ava, Daniel F. Quevedo, Boya Zhang, Yazmin Hernandez, Anthony Berardi, William Brown, Sophia Lee Enzyme‐based Synthetic Protein Nanoparticles as Colloidal Antioxidants. Advanced Therapeutics. 2023
    https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.202300007
  10. Santiago, J. I., Ahmed, I., Hahn, J., Rubino, A., Dubnau, D., Neiditch, M. B., & Mickolajczyk, K. J. (2025). Reversible DNA condensation drives natural transformation. bioRxiv, 2025-07.
    https://www.biorxiv.org/content/10.1101/2025.07.24.666597v1.full
  11. Studer, Tetiana, Daria Morina, Inga S. Shchelik, and Karl Gademann.  Biohybrid Microswimmers for Antibiotic Drug Delivery Based on a Thiol‐Sensitive Release Platform. Chemistry-A European Journal. 2023
    https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202203913
  12. Suzhou University. A combined drug delivery system based on T cell adapter and adoptive T cells, and its preparation method and application. (CN120459292A)
    https://patents.google.com/patent/CN120459292A/en?q=(broadpharm)&num=100&oq=broadpharm&sort=new
  13. Thomas Colace, Yusuf Erkul, Jieni Xu, Burak Yilmaz. Compositions and methods for delivery of agents. (US20250235411A1)
    https://patents.google.com/patent/US20250235411A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=29
  14. Zhao, Z., Ledezma, D. K., Affonso de Oliveira, J. F., Omole, A. O., & Steinmetz, N. F. (2025). A cowpea mosaic virus adjuvant conjugated to liposomes loaded with tumor cell lysates as an ovarian cancer vaccine. Nature Communications, 16(1), 5047.
    https://www.nature.com/articles/s41467-025-60239-w
  15. Zhongchao ZHAO, Nicole F. Steinmetz. Antigen loaded liposomes for combination with plant virus nanoparticle adjuvants. (WO2025006780A1)
    https://patents.google.com/patent/WO2025006780A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=11
  16. 泰孝 安楽, Yasutaka Anraku, 純平 乗松, Jumpei NORIMATSU, 隼斗 水野, Hayato Mizuno. Cationic polymer having phosphonium groups and polymer particles or pharmaceutical composition containing the same. (JP2024152597A)
    https://patents.google.com/patent/JP2024152597A/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=15
  17. 泰孝 安楽, 純平 乗松, 隼斗 水野. Phosphonium group-containing cationic polymer, and polymer particles and pharmaceutical composition containing same. (WO2024214632A1)
    https://patents.google.com/patent/WO2024214632A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=13
  18. 费利克斯·拜尔, 黛博拉·基奥-斯特罗卡, 丹尼尔·坎迪纳斯·冯·阿尔贝蒂尼, 尼古拉斯·梅林. Methods for preventing, delaying progression or treating cholestasis and/or fibrosis associated with cholestasis. (CN119585429A)
    https://patents.google.com/patent/CN119585429A/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=21
  19. 郑毅然, 马思琪, 刘宁, 赵磊. Modified PD-1 antibody and preparation method and application thereof. (CN116925228A)
    https://patents.google.com/patent/CN116925228A/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=21




BroadPharm의 모든 제품들을 만나보세요!



BroadPharm - Official Distributor in South Korea "Morebio" 한국 공식 대리점 "모아바이오"



제품 번호

 

bp-50123

 


제품 특징


MagicLink™ Site Specific Biotinylation Kits provide optimized reagents for biotinylating antibodies. Biotin is a small, naturally occurring vitamin that binds with high affinity to avidin and avidin-like proteins. Biotinylated antibodies typically retain biological activity because the biotin group is relatively small. Current bintinylation methods, such as amine-NHS ester and converting amine to thiol and then use maleimide chemistry, will produce random biotin on the antibody. In some cases, labeling in some Fab areas could block antigens binding. With site specific biotinylation chemistry, biotin linkers are inserted to thiol-bridge locations and do not affect antibody-antigen binding (Fig.1). It will help increase the sensitivity of bio assay such as ELISA, Western Blot, etc.

This conjugation reaction is simple, site-specific, and efficient. These kits include biotin linker, reaction buffer, protein concentrator, DMSO, and TCEP. The user can follow easy protocol and get the conjugation in less than 2 hours.

These kits are specifically optimized to label antibodies at scales of 100 ug and 1 mg. The kits are packaged as convenient single-use microtubes, eliminating difficulties associated with weighing small quantities of reagent.

 

Components


The kit is mainly to label primary antibodies, secondary antibodies, soluble MHC/peptide complex (monomer); recombinant protein. In biology, the biotinylated molecules are used for the applications below.

  • FC
  • ELISA Detection
  • ELISA
  • WB
  • IHC-P
  • ICFC



BroadPharm의 모든 제품들을 만나보세요!



BroadPharm - Official Distributor in South Korea "Morebio" 한국 공식 대리점 "모아바이오"

목록