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Antibody System

[Antibodysystem] Research Grade Anti-Human TSHR/LGR3 (K1 70)

Cat-No. DHD18101

AntibodySystem는 Primary Antibody Biosimilar - Research Grade

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Novel insight on Thyroid Stimulating Hormone Receptor

Thyroid hormone is one of the most important metabolic hormones. When the hypothalamus is stimulated, thyroid hormone-releasing hormone (TRH) is released, and the secretion of TRH further stimulates the pituitary to release thyroid stimulating hormone (TSH). Thyroid stimulating hormone receptor (TSHR) is a receptor for TSH, activated TSHR can be coupled to the stimulatory Gs protein to stimulate the production of thyroid hormone. TSHR a subunit can be dissociated from the B subunit to become an antigen and could become an autoantigen that induces various types of antibodies against TSHR. Autoantibodies (such as M22 or K1-70) can cause abnormal secretion of TSHR and lead to diseases such as Graves’ disease or hypothyroidism. These diseases are affecting hundreds of millions of patients worldwide, however, the basis of TSH and antibody-mediated TSHR activation is unclear. Owing to its disease relevance, TSHR is an attractive target for drug discovery.

제품 설명

Research Grade Anti-Human TSHR/LGR3 (K1 70)

제품 번호

DHD18101

제품 특징

Catalog No.

DHD18101

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG

Clonality

Monoclonal

Target

Thyroid-stimulating hormone receptor, TSH-R, TSHR, Thyrotropin receptor, LGR3

Concentration

1.7 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P16473

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.