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제품 설명 

Influenza A nucleoprotein, antibody

제품 번호

Cat. 3IN5

제품 특징

• Cat.#

  3IN5

• Recombinant MAbs:

  FA32, FA35, FA38, FA58
  
  Recombinant antibody expressed in a mammalian cell line. Full-size IgG sequence derived from rabbit B cells.
  
  FA52
  
  Recombinant chimeric antibody expressed in a mammalian cell line. Composed of original wild type variable domains of rat derived MAb and human IgG1 constant domains.

  
  FA91, FA94
  
  Recombinant chimeric antibody expressed in a mammalian cell line. Composed of original wild type variable domains of sheep derived MAb and human IgG1 constant domains.

• MAbs in vitro

  FA17
  
  Mouse monoclonal antibody produced in bioreactor. Hybridoma clone derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice.

• MAbs in vivo

  F8, InA108, InA180, InA224, InA245
  
  Mouse monoclonal antibody produced in ascites. Hybridoma clone derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice.

• Immunogens

  Recombinant nucleoprotein of influenza virus type A strain H1N1 A/California/07/2009 for FA17, FA32, FA35, FA38, FA52, FA58, FA91, FA94
  
  Purified influenza virus type A strain H1N1 for F8, InA108, InA180, InA224, InA245

• Specificity:

  Influenza virus type A (nucleoprotein). No cross-reactivity to NP of influenza B virus.
  The following strains were tested with MAbs FA17, FA32, FA35, FA38, FA52, FA58, FA91, and FA94 and they all reacted with these strains:

  

  
  

  Testing was carried out using corresponding recombinant nucleoproteins or lysates of purified viral preparations.
  All antibodies are not cross-reactive to influenza B virus (<0.1%). Testing was carried out using lysates of purified viral preparations of influenza B/Colorado/06/2017.
  MAbs FA17, FA32, FA35, FA38, FA52, FA58, FA91, FA94 were tested with SARS-CoV-2 nucleoprotein and demonstrated no cross-reaction (<0.05%)

• MAb isotypes:

  IgG for FA32, FA35, FA38, FA58
  
  IgG1 for FA17, FA52, FA91, FA94, InA108, InA224
  
  IgG2a for F8
  
  IgG2b for InA245
  
  IgG3 for InA180

• Applications:

  MAb F8 can be used in immunocytochemistry. MAb F8 inhibits viral reproduction after fatty acid acylation.
  
  MAbs InA108 and InA245 detect influenza A nucleoprotein in Western blotting.
  
  All MAbs are working in ELISA.
  
  Recommended pairs for influenza A nucleoprotein detection: 

  

• Purification:

  Protein A chromatography for FA17, FA32, FA35, FA38, FA52, FA58, FA91, FA94, InA108, InA180, InA224, InA245
  
  Protein G chromatography for F8

• Presentation:

  PBS, pH 7.4, 0.09 % sodium azide (NaN3) for FA17, FA32, FA35, FA38, FA52, FA58, FA91, FA94, F8, InA108, InA224, InA245
  
  50 mM sodium citrate, 150 mM NaCl, pH 6.0, 0,09 % azide (NaN3) for InA180

• Storage:

  +4 °C (+2 … +8 °C allowed)

• Material safety note:

  This product is sold for research or further manufacturing use only. Standard Laboratory Practices should be followed when handling this material.

  Product contains sodium azide as a preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

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