Signosis는 Reporter Stable Cell Lines 제품군과 연관 키트들을 전문적으로 제공하는 미국의 제조업체 입니다.

제품정보

제품명: EGFR (Del19 (del747-753InsS)) BaF3 Stable Cell Line

Cat-No.: EL-011

Size: vial of 2-3 x 10^6 cells

Format: Frozen

제품설명

Epidermal growth factor receptor (EGFR) is a cell-surface receptor with intrinsic intracellular protein-tyrosine kinase (TK) activity. Ligand binding induces EGFR dimerization and phosphorylation, leading to the activation of EGFR signaling pathway. In several malignancies such as non-small cell lung cancer (NSCLC), EGFR signaling is deregulated due to mutations in EGFR, which results in uncontrolled proliferation and migration of tumor cells. EGFR mutations can lead to oncogene-addicted cancers, where the tumor cells depend on the mutated EGFR for cell survival and malignant phenotype. One of the most common EGFR mutations found in human patients is L858R substitution in exon 21, within the activation loop of EGFR. Patients with this mutation are sensitive to EGFR tyrosine kinase inhibitors (TKIs) such as gefitinib or erlotinib, whereas patients with wild type EGFR are not sensitive to TKI. Another clinically relevant mutation associated with acquired gefitinib and erlotinib resistance is T790M, found in exon 20. Cells expressing EGFR with both L858R and T790M mutations are resistant to induced apoptosis in the presence of gefitinib or erlotinib. 

We offer EL-011, a BaF3 stable cell line expressing EGFR (E19del (del747-753InsS)) . The EGFR exon 19 mutation is an 11-18 bp in-frame deletion around the ATP-binding site encoded in exon 19 of the EGFR gene, observed in ~15-20% of lung cancer patients. This cell line can be used to study the molecular mechanism underlying susceptibility of tumors to the drugs (i.e. gefitinib and erlotinib) as well as screening and validating new TKIs.

관련데이터

Signosis- Exclusive Distributor in Republic of Korea "Morebio" 

Signosis의 한국 독점 대리점 "모아바이오"