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제품 설명

Collagen Type V (Atelocollagen), Bovine, 1 mg

제품 번호

8052012

제품 특징

Description

Purified Bovine Collagen Type V from bovine placenta (atelocollagen).

Type V collagen is a fibrillar collagen that plays a vital role in the fibrillation of types I and III collagen, ultimately contributing to optimal fibrillary formation and tissue quality. It is an essential component of the bone matrix, corneal stroma, and the interstitial matrix of muscles, liver, lungs, and placenta. However, dysregulation of collagen fibrillogenesis is a hallmark of several subtypes of Ehlers-Danlos syndrome (EDS).
 
Studies have shown that Type V collagen is responsible for regulating the heterotypic fiber diameter and is considered a regulatory fibril-forming collagen. It is a part of the family of collagen proteins consisting of Collagen I- Collagen XXVIII, which support and strengthen many tissues including skin, bones, muscles, and ligaments.
 
Type V collagen is associated with the COL5A1 gene which provides instructions to produce Collagen V. Like other collagens, it is made up of procollagen molecules.
 
Understanding the importance of Type V collagen in the body can help researchers understand the role it plays in maintaining tissue quality and preventing the onset of EDS.

Data/Specifications: 

Description: Purified Bovine Collagen Type V from bovine placenta (atelocollagen).

Form: Lyophilized, salt free, sterile 1mg / vial

Source: Bovine placenta

Purity: Bovine Collagen Type V (Atelocollagen) > 98%

Purification: Collagen was extracted from washed dissected tissue into dilute acetic after mild pepsin treatment- Collagen Type V was purified by using differential salt precipitation.

Sterility: Passed sterility test for bacteria and fungi. 

Application: Cell culture (coating)

Reconstitution: Dissolve in 20 mM acetic acid. Suspension should be shaken or stirred for several hours or overnight between 2-8°C. Material is dissolved when it appears homogeneous, with no schlieren pattern (light refraction due to differing protein concentrations in the suspension). Recommended concentration 1-5 mg/ml. After dissolution store 1 month at +4°C.

Storage: Lyophilized protein: shipping at ambient temperature, long term storage (2 years) at -20°C or lower. Storage of reconstituted protein 1 month at +4°C