Proteogenix는 Primary Antibody Biosimilar - Research Grade
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제품 설명
제품 번호
PX-P6274
제품 특징
| Product name | Human CD20/MS4A1 recombinant protein |
|---|---|
| Uniprot ID | P11836 |
| Origin species | Homo sapiens (Human) |
| Expression system | Prokaryotic expression |
| Molecular weight | 19.58 kDa |
| Protein delivered with Tag? | N-Terminal His & N-Terminal Trx Tags |
| Purity estimated | >85% by SDS-PAGE |
| Buffer | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Delivery condition | Dry Ice |
| Storage condition | 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection) |
| Brand | ProteoGenix |
| Host species | Escherichia coli (E.coli) |
| Applications | ELISA,WB |
| Fragment Type | Ile143-Ser188 |
| Aliases /Synonyms | B-lymphocyte surface antigen B1, Membrane-spanning 4-domains subfamily A member 1, MS4A1, Leukocyte surface antigen Leu-16, B-lymphocyte antigen CD20, Bp35, CD20 |
| Reference | PX-P6274 |
| Note | For research use only |
The human CD20/MS4A1 recombinant protein is a type I membrane protein composed of a single extracellular loop, a single transmembrane domain, and a cytoplasmic tail. It is expressed on the surface of B-cells and is involved in B-cell activation and proliferation.
The activity of the human CD20/MS4A1 recombinant protein is mediated by its interaction with other proteins, such as CD19 and CD21, which are involved in B-cell activation and proliferation. The CD20/MS4A1 protein is also involved in the regulation of B-cell differentiation and maturation.
The human CD20/MS4A1 recombinant protein is a promising target for the development of antibody-drug conjugates for the treatment of B-cell malignancies. Antibodies targeting the CD20/MS4A1 protein have been successfully used in clinical trials, demonstrating their potential as an effective treatment for various B-cell malignancies.
QC & Validation Data
Immobilized Human CD20/MS4A1 recombinant protein (cat. No.PX-P6274) at 0.5µg/mL (100µL/well) can bind to Ocrelizumab Biosimilar - Anti-MS4A1, CD20 mAb (cat. No.PX-TA1162) in indirect ELISA with Goat Anti-Human IgG secondary antibody coupled with HRP measured by OD450
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