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제품설명

Cord Blood CD34+ Stem/Progenitor Cells, Single Donor, Frozen

제품번호

CP130

CB3400.5C / size: 0.5 milion/vial 

CB3401C / size: 1 milion/vial 

제품특징

Description

CD34 is a glycosylated transmembrane protein and represents a well-established marker for human hematopoietic stem and progenitor cells in peripheral blood, bone marrow, and cord blood. CD34+ cells are self-renewing, multipotent stem cells that give rise to all blood cells of the immune system through a process called hematopoiesis. As hematopoietic stem cells progress through hematopoiesis they generate the myeloid (monocytes, macrophages, granulocytes, megakaryocytes, dendritic cells, erythrocytes) and lymphoid (T cells, B cells, NK cells) lineages. The highly specialized cells that arise from hematopoietic stem cells work collaboratively in defending the body against infection and disease.

Human cord blood CD34+ stem and progenitor cells are positively selected using immunomagnetic anti-CD34 (clone QBEND10) microbeads from the mononuclear cell fraction. Isolated cells are characterized by flow cytometry prior to cryopreservation to ensure a highly pure and viable cell population.

Cells were obtained using Institutional Review Board (IRB) approved consent forms and protocols.

Additional information

Publications

Halkias et al. (2015) Conserved and Divergent Aspects of Human T-cell Development and Migration in Humanized Mice. Immunol Cell Biol 1-11. doi:10.1038/icb.2015.38.

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Cleyrat et al. (2017) Gene Editing Rescue of a Novel MPL Mutant Associated with Congenital Amegakaryocytic Thrombocytopenia. Blood Advances 1: 1815-1826. doi.org/10.1182/bloodadvances.201600291.

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Takahashi et al. (2018) Enhanced Antibody Responses in a Novel NOG Transgenic Mouse with Restored Lymph Node Organogenesis. Front. Immunol 1(17). doi.org/10.3389/fimmu.2017.02017.

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Ito et al. (2020) Bovine β-Lactoglobulin-Induced Passive Systemic Anaphylaxis Model Using Humanized NOG hIL-3/hGM-CSF Transgenic Mice. Int Immunol. DOI: 10.1093/intimm/dxaa067.

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