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Antibodysystem

[Antibodysystem] Recombinant Human TSHR/LGR3 Protein, C-Fc

Cat-No. EHD18102

AntibodySystem는 Primary Antibody Biosimilar - Research Grade

제품을 전문적으로 생산하는 20년의 경험이 있는 High Quality 제조사입니다.

Novel insight on Thyroid Stimulating Hormone Receptor

Thyroid hormone is one of the most important metabolic hormones. When the hypothalamus is stimulated, thyroid hormone-releasing hormone (TRH) is released, and the secretion of TRH further stimulates the pituitary to release thyroid stimulating hormone (TSH). Thyroid stimulating hormone receptor (TSHR) is a receptor for TSH, activated TSHR can be coupled to the stimulatory Gs protein to stimulate the production of thyroid hormone. TSHR a subunit can be dissociated from the B subunit to become an antigen and could become an autoantigen that induces various types of antibodies against TSHR. Autoantibodies (such as M22 or K1-70) can cause abnormal secretion of TSHR and lead to diseases such as Graves’ disease or hypothyroidism. These diseases are affecting hundreds of millions of patients worldwide, however, the basis of TSH and antibody-mediated TSHR activation is unclear. Owing to its disease relevance, TSHR is an attractive target for drug discovery.

제품 설명

Recombinant Human TSHR/LGR3 Protein, C-Fc

제품 번호

EHD18102

제품 특징

Catalog No.

EHD18102

Expression system

Mammalian Cells

Species

Homo sapiens (Human)

Protein length

Met22-Gln289

Predicted molecular weight

57 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

P16473

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.