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제품 설명

Lumican, Antibody, 100 ug

제품 번호

1042007

제품 특징

Description

Lumican (LUM) monoclonal antibody (mouse, clone Lum-1) to detect a protein epitope in lumican. Liquid, 1 mL/vial. Concentration: 0.1 mg/mL

Lumican (LUM) is the major keratan sulfate proteoglycan of the cornea and it binds collagen fibrils. In noncorneal tissues, lumican is present as a low or nonsulfated glycoprotein and has been found in the aorta, cartilage, liver, skeletal muscle, kidney, pancreas, brain, placenta and lung. Complications of the cornea have been confirmed using lumican-null mice. These mice exhibit corneal opacity, skin fragility, and impaired collagen fibrillogenesis. More recent studies show lumican has an integral role in cell migration, adhesion and proliferation. The expression of lumican has also been examined in breast, pancreatic and colorectal cancer. The affect of lumican depends on the type of cancer as it has been shown to have both a positive and negative affect on tumor growth.

Specifications:

• Clone: Lum-1
• Host: Mouse
• Isotype: IgM
• Purity: Affinity purified on thiophilic column
• Form: Liquid, 1 mL/vial
• Concentration: 0.1 mg/mL
• Storage: -20°C.
• Specificity: This Lumican antibody recognises a protein epitope in lumican derived from human, bovine, porcine & mouse tissues.