Signosis는 Reporter Stable Cell Lines 제품군과 연관 키트들을 전문적으로 제공하는 미국의 제조업체 입니다.

제품정보

제품명: HER2 (A775_G776insYVMA) BaF3 Stable Cell Line

Cat-No.: EL-0033

Size: vial of 2-3 x 10^6 cells

Format: Frozen

제품설명

The proto-oncogene human epidermal growth factor receptor 2 (HER2) gene also known as ERBB2 is a member of the ERBB/HER RTK family which is comprised of EGFR (EGFR/HER1/ERBB1), HER3/ERBB3, and HER4/ERBB4. This gene encodes for a transmembrane glycoprotein receptor with an intracellular domain with tyrosine kinase activity which is responsible for the activation of intracellular signal transduction pathways controlling epithelial cell growth, differentiation, and angiogenesis. Aberrations of the HER2 gene which usually leads to increased receptor signaling have been observed in many different types of cancer.
 
ERBB2 (HER2) A775_G776insYVMA results in the insertion of four amino acids in the protein kinase domain of the Erbb2 (Her2) protein between amino acids 775 and 776 which leads to constitutive phosphorylation of Erbb2 (Her2).

제품특징

- ErbB/HER signaling pathway 연구에 사용 가능.

• - Drugs 및 compounds 연관 스크리닝 및 평가에 사용 가능.
  - 형질전환된 Her2 gene sequence 및 발현 단백질 확인됨
• - Viral-vector free.
• - Mycoplasma-free.

Signosis- Exclusive Distributor in Republic of Korea "Morebio" 

Signosis의 한국 공식 독점 대리점 "모아바이오"