Broadpharm는 생화학 제품과 연구용 화학 시약을 제공하는 글로벌 바이오 및 제약 회사입니다.

제품 설명 

SM-102

제품 번호

BP-25499

제품 특징

SM-102 is a synthetic ionizable lipid which is used in combination with other lipids to form lipid nanoparticles (LNP) for drug delivery. These are used for the delivery of mRNA-based COVID-19 vaccines. The pKa is 6.68. Reagent grade, for research purpose.

• Catalog:

   

  BP-25499

• Name:

   

  SM-102

• Formula:

   

  C44H87NO5

• MW:

   

  710.2

• CAS:

   

  2089251-47-6

• Purity:

   

  98%

• Ships Within:

   

  24 Hours

• Storage Condition:

   

  -20°C

• Solubility:

   

  Ethanol, DMSO, DMF

• Shipping:

   

  Ambient Temperature

• Availability:

   

  In Stock

• NMR:

   

  View

• SDS:

   

  View

Product Citations

1. 
   https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.5c00614
2. Banda, O., Adams, S. E., Omer, L., Jung, S. K., Said, H., Phoka, T., ... & Kurre, P. (2025). Restoring hematopoietic stem and progenitor cell function in Fancc−/− mice by in situ delivery of RNA lipid nanoparticles. Molecular Therapy Nucleic Acids, 36(1).
   https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(24)00310-X
3. Basham, C., Haney, M., Zhao, Y., Lukyanov, K. A., Kim, K., Baysal, A., ... & Ramsey, J. D. (2025). PEG-Free Tunable Poly (2-Oxazoline) Lipids Modulate LNP Biodistribution and Expression In Vivo after Intramuscular Administration. bioRxiv, 2025-06.
   https://www.biorxiv.org/content/10.1101/2025.06.05.657891v1.full
4. Bhagchandani, S. H., Ehrenzeller, S., Pires, I. S., Chaudhary, N., Booth, C. J., Guedes de Sá, K. S., ... & Iwasaki, A. (2025). Bioactive Enhanced Adjuvant Chemokine Oligonucleotide Nanoparticles (BEACONs) for Mucosal Vaccination Against Genital Herpes. bioRxiv, 2025-07.
   https://www.biorxiv.org/content/10.1101/2025.07.31.667899v1.full
5. Bhattacharya, A., Jan, L., Burlak, O., Li, J., Upadhyay, G., Williams, K., ... & Dey, A. K. (2024). Potent and long-lasting humoral and cellular immunity against varicella zoster virus induced by mRNA-LNP vaccine. npj Vaccines, 9(1), 72.
   https://www.nature.com/articles/s41541-024-00865-5
6. Binici, B., Borah, A., Watts, J. A., McLoughlin, D., & Perrie, Y. (2025). The influence of citrate buffer molarity on mRNA-LNPs: Exploring factors beyond general critical quality attributes. International Journal of Pharmaceutics, 668, 124942.
   https://doi.org/10.1016/j.ijpharm.2024.124942
7. Binici, B., Rattray, Z., Schroeder, A., & Perrie, Y. (2024). The role of biological sex in pre-clinical (mouse) mRNA vaccine studies. Vaccines, 12(3), 282.
   https://doi.org/10.3390/vaccines12030282
8. Borah, A., Giacobbo, V., Binici, B., Baillie, R., & Perrie, Y. (2025). From in vitro to in Vivo: The Dominant role of PEG-Lipids in LNP performance. European Journal of Pharmaceutics and Biopharmaceutics, 114726.
   https://doi.org/10.1016/j.ejpb.2025.114726
9. Borah, A., Giacobbo, V., Binici, B., Baillie, R., & Perrie, Y. (2025). From in vitro to in vivo: The Dominant role of PEG-Lipids in LNP performance. European Journal of Pharmaceutics and Biopharmaceutics, 114726.
   https://www.sciencedirect.com/science/article/pii/S0939641125001031
10. Buckley, M., Arainga, M., Maiorino, L., Pires, I. S., Kim, B. J., Kaczmarek Michaels, K., ... & Irvine, D. J. (2024). Visualizing lipid nanoparticle trafficking for mRNA vaccine delivery in non-human primates. bioRxiv, 2024-06.
    https://doi.org/10.1101/2024.06.21.600088
11. Coleman, H. J., Rauch, A., Langsfeld, E., Anderson, K., Parlikar, U., Funke, H. H., ... & Randolph, T. W. (2025). Lipid-free, thermostable mRNA vaccines prepared using atomic layer deposition. Journal of Pharmaceutical Sciences, 104066.
    https://www.sciencedirect.com/science/article/abs/pii/S0022354925005209
12. Coussens, E. Exploring the potential of CRISPR/Cas9 lipid nanoparticles to cure HIV.
    https://lib.ugent.be/catalog/rug01:003212736
13. Cryer, A. M., Dosta, P., Dion, M. Z., de la Parra Soto, L., Amar-Lewis, E., Garcia de Leon Carmona, G., ... & Artzi, N. (2025). Restoration of cGAS in cancer cells promotes antitumor immunity via transfer of cancer cell–generated cGAMP. Proceedings of the National Academy of Sciences, 122(45), e2409556122.
    https://www.pnas.org/doi/abs/10.1073/pnas.2409556122
14. De Peña, A. C., Zimmer, D., Gutterman-Johns, E., Chen, N. M., Tripathi, A., & Bailey-Hytholt, C. M. (2024). Electrophoretic Microfluidic Characterization of mRNA-and pDNA-Loaded Lipid Nanoparticles. ACS Applied Materials & Interfaces.
    https://pubs.acs.org/doi/abs/10.1021/acsami.4c00208
15. Edmonds, K. K., Wilkinson, M. E., Strebinger, D., Chen, H., Lash, B., Schaefer, C. C., ... & Zhang, F. (2025). Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons. Nature Communications, 16(1), 6079.
    https://www.nature.com/articles/s41467-025-61321-z
16. Edmonds, K. K., Wilkinson, M. E., Strebinger, D., Chen, H., Lash, B., Schaefer, C. C., Zhu, S., Liu, D., Zilberzwige-Tal, S., Ladha, A., Walsh, M. L., Frangieh, C. J., Vaz Reay, N. A., Macrae, R. K., Wang, X., & Zhang, F. (2025). Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons. Nature communications, 16(1), 6079
    https://doi.org/10.1038/s41467-025-61321-z
17. Eric Andrew Appel, Emily Louise MEANY, Shih Hao Ou. Compositions and methods for delivery of nucleic acid therapeutics. (WO2025035015A1)
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18. Fairlamb, M., Kumru, O. S., Hickey, J. M., Elbaz, N. M., Bevernaegie, R., Vander Straten, A., ... & Volkin, D. B. (2025). Developability assessments with four mRNA-LNP vaccine formulations comparing mouse immunogenicity, structural attributes, and stability profiles. VeriXiv, 2(275), 275.
    https://verixiv.org/articles/2-275/v1?src=rss
19. Felgner, J., Hernandez-Davies, J. E., Strahsburger, E., Silzel, E., Nakajima, R., Jain, A., ... & Liang, L. (2025). Lipid Nanoparticle Development for A Fluvid mRNA Vaccine Targeting Seasonal Influenza and SARS-CoV-2. npj Vaccines, 10(1), 123.
    https://www.nature.com/articles/s41541-025-01153-6
20. Felgner, J., Hernandez-Davies, J.E., Strahsburger, E. et al. Lipid Nanoparticle Development for A Fluvid mRNA Vaccine Targeting Seasonal Influenza and SARS-CoV-2. npj Vaccines 10, 123 (2025)
    https://doi.org/10.1038/s41541-025-01153-6
21. Forrester, J., Davidson, C. G., Blair, M., Donlon, L., McLoughlin, D. M., Obiora, C. R., ... & Perrie, Y. (2025). Low-cost microfluidic mixers: are they up to the task?. Pharmaceutics, 17(5), 566.
    https://www.mdpi.com/1999-4923/17/5/566
22. Forrester, J., Davidson, C. G., Blair, M., Donlon, L., McLoughlin, D. M., Obiora, C. R., ... & Perrie, Y. (2025). Low-cost microfluidic mixers: are they up to the task?. Pharmaceutics, 17(5), 566.
    https://www.mdpi.com/1999-4923/17/5/566
23. Ghosh, A. R., Habib, R., Mishra, N., Roark, R. S., Akauliya, M., Albowaidey, A. A., ... & Batista, F. D. (2025). Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization. bioRxiv, 2025-06.
    https://www.biorxiv.org/content/10.1101/2025.06.12.659380v1.full
24. Giacobbo, V. (2025). End-to-end optimization of lipid nanoparticle manufacturing for mRNA delivery.
    https://stax.strath.ac.uk/concern/theses/vx021f609
25. Heiser, B. J., Lewis, M. M., Zerankeshi, M. M., Netemeyer, E. K., Hernandez, A. M., Marras, A. E., & Ghosh, D. (2025). Systematic screening of excipients to stabilize aerosolized lipid nanoparticles for enhanced mRNA delivery. RSC pharmaceutics.
    https://pubs.rsc.org/en/content/articlehtml/2025/pm/d5pm00061k
26. Hołubowicz, R., Du, S. W., Felgner, J., Smidak, R., Choi, E. H., Palczewska, G., ... & Palczewski, K. (2024). Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations. Nature Biomedical Engineering, 1-22.
    https://www.nature.com/articles/s41551-024-01296-2
27. https://onlinelibrary.wiley.com/doi/full/10.1002/jimd.70122
    Lipid
28. https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.5c00614
    Lipid
29. https://pubs.acs.org/doi/full/10.1021/acsnano.5c15903
    Lipid
30. https://www.biorxiv.org/content/10.1101/2025.10.21.683660v1.full
    Lipid
31. https://www.jci.org/articles/view/194080
    Lipid
32. https://www.mdpi.com/1999-4923/18/1/50
    Lipid
33. https://www.nature.com/articles/s41541-025-01349-w
    Lipid
34. https://www.pnas.org/doi/abs/10.1073/pnas.2409556122
    Lipid
35. https://www.sciencedirect.com/science/article/abs/pii/S0022354925005209
    Lipid
36. https://www.sciencedirect.com/science/article/pii/S0168365925009800
    Lipid
37. Hussain, M., Binici, B., O’Connor, L., & Perrie, Y. (2024). Production of mRNA lipid nanoparticles using advanced crossflow micromixing. Journal of Pharmacy and Pharmacology, 76(12), 1572-1583.
    https://academic.oup.com/jpp/article/76/12/1572/7816331
38. Hussain, M., Ferguson-Ugorenko, A., Macfarlane, R., Orr, N., Clarke, S., Wilkinson, M. J., ... & Perrie, Y. (2025). Mind the age gap: expanding the age window for mRNA vaccine testing in mice. Vaccines, 13(4), 370.
    https://www.mdpi.com/2076-393X/13/4/370
39. Hussain, M., Muglikar, A., Brain, D. E., Plant-Hately, A., Liptrott, N., McLoughlin, D. M., & Perrie, Y. (2025). Redefining LNP composition: phospholipid and sterol-driven modulation of mRNA expression and immune outcomes. RSC Pharmaceutics.
    https://pubs.rsc.org/en/content/articlehtml/2025/pm/d5pm00150a
40. Jakub GOŁĄB, Dominika Nowis, Joanna Kowalska, Jacek Jemielity, Piotr SKLEPKIEWICZ, Mirosław ŚMIETAŃSKI, Olga SOKOŁOWSKA, Paweł Turowski, Hanna KĘDZIERSKA, Marek Baranowski, Tomasz ŚPIEWLA, Agnieszka Popielec. Modified rna for the treatment of cfdna-associated diseases. (WO2025176838A1)
    https://patents.google.com/patent/WO2025176838A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=2
41. Jalil, S., Keskinen, T., Juutila, J., Maldonado, R. S., Euro, L., Suomalainen, A., ... & Wartiovaara, K. (2024). Genetic and functional correction of argininosuccinate lyase deficiency using CRISPR adenine base editors. The American Journal of Human Genetics, 111(4), 714-728.
    https://www.cell.com/ajhg/fulltext/S0002-9297(24)00077-6
42. Jalili, S., Hosn, R. R., Ko, W. C., Afshari, K., Dhinakaran, A. K., Chaudhary, N., ... & Irvine, D. J. (2025). Leveraging tissue-resident memory T cells for non-invasive immune monitoring via microneedle skin patches. medRxiv, 2025-03.
    https://doi.org/10.1101/2025.03.17.25324099
43. Jeon, J. H., Zhu, H., Qin, J., Wang, L., Mou, S., Langston, L. K., ... & Cui, X. (2025). Lipid Nanoparticles Formulated with a Novel Cholesterol-Tailed Ionizable Lipid Markedly Increase mRNA Delivery Both in vitro and in vivo. International Journal of Nanomedicine, 9389-9405.
    https://www.tandfonline.com/doi/full/10.2147/IJN.S527822
44. Kannan, R., Tran, B., Le, Q., Hohenwarter, L., Chao, P. H., Brar, V., ... & Li, S. D. (2025). Incorporation of a polyamine into lipid nanoparticles increases the endosomal release and transfection of nucleic acids without toxicity. Journal of Controlled Release, 114366.
    https://www.sciencedirect.com/science/article/pii/S0168365925009800
45. Keskinen, T., Jalil, S., Gümüşoğlu, I., Juutila, J., Kestilä, N., Kuuluvainen, E., ... & Hyvönen, M. E. (2026). Genetic Correction of the Most Common Mutation Causing Primary Hyperoxaluria Restores Enzyme Localization and Oxalate Metabolism. Journal of Inherited Metabolic Disease, 49(1), e70122.
    https://onlinelibrary.wiley.com/doi/full/10.1002/jimd.70122
46. Khalifeh, M., Oude Egberink, R., Roverts, R., & Brock, R. (2025). Incorporation of ionizable lipids into the outer shell of lipid-coated calcium phosphate nanoparticles boosts cellular mRNA delivery. International Journal of Pharmaceutics, 670, 125109.
    https://www.sciencedirect.com/science/article/pii/S0378517324013437
47. Kim, S. C., Felgner, J., Soto, M. S., Hitchcock, L., Silzel, E. K., Beares, H., ... & Wagar, L. E. (2025). Human CD4 T cells are a functional target for lipid nanoparticle-based mRNA vaccines. mBio, e02254-25.
    https://journals.asm.org/doi/full/10.1128/mbio.02254-25
48. Ko, K. H., Lee, S. H., Choi, Y. H., Kang, S. M., Yang, H. S., Lee, S. M., ... & Cha, S. B. (2025). Lipid nanoparticle encapsulated TLR3 agonist adjuvant elicits potent T cell immunity against cancer and viruses. npj Vaccines.
    https://www.nature.com/articles/s41541-025-01349-w
49. Kukushkin, I., Vasileva, O., Kunyk, D., Kolmykov, S., Sokolova, T., Muslimov, A., ... & Reshetnikov, V. (2024). Effects of Various Poly (A) Tails on Luciferase Expression. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 18(3), 263-274.
    https://link.springer.com/article/10.1134/S1990750824600055
50. Lee, Y., Park, J. S., Jeon, H., Lim, S. G., Lee, D., & Koo, H. (2025). Lung-targeted delivery of TRAIL and BAK mRNA by optimized lipid nanoparticles for in vivo lung metastasis. Chemical Engineering Journal, 167379.
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51. Lewis, M. M., Beck, T. J., & Ghosh, D. (2023). Applying machine learning to identify ionizable lipids for nanoparticle-mediated delivery of mRNA. bioRxiv, 2023-11.
    https://doi.org/10.1101/2023.11.09.565872
52. Li, Y., Ambati, S., Meagher, R. B., & Lin, X. (2025). Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model. npj Vaccines, 10(1), 24.
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53. Lindsay, S., Hussain, M., Binici, B., & Perrie, Y. (2025). Exploring the challenges of lipid nanoparticle development: the in vitro–in vivo correlation gap. Vaccines, 13(4), 339.
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54. Ma, Y., Fung, V., VanKeulen-Miller, R., Tiwade, P. B., Narasipura, E. A., Gill, N. A., & Fenton, O. S. (2025). A Metabolite Co-Delivery Strategy to Improve mRNA Lipid Nanoparticle Delivery. ACS Applied Materials & Interfaces, 17(18), 26202-26215.
    https://pubs.acs.org/doi/abs/10.1021/acsami.4c22969
55. Ma, Y., VanKeulen-Miller, R., & Fenton, O. S. (2025). mRNA lipid nanoparticle formulation, characterization and evaluation. Nature Protocols, 1-34.
    https://www.nature.com/articles/s41596-024-01134-4
56. Mae LEWIS, Debadyuti GHOSH. Aerosolized lipid nanoparticles and uses thereof. (WO2024107702A1)
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57. McMillan, C., Druschitz, A., Rumbelow, S., Borah, A., Binici, B., Rattray, Z., & Perrie, Y. (2024). Tailoring lipid nanoparticle dimensions through manufacturing processes. RSC pharmaceutics.
    https://pubs.rsc.org/en/content/articlehtml/2024/pm/d4pm00128a
58. Meany, E. L., Klich, J. H., Jons, C. K., Mao, T., Chaudhary, N., Utz, A., ... & Appel, E. (2024). Generation of an inflammatory niche in an injectable hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines. bioRxiv, 2024-07.
    https://doi.org/10.1101/2024.07.05.602305
59. Meany, E. L., Klich, J. H., Jons, C. K., Mao, T., Chaudhary, N., Utz, A., ... & Appel, E. (2025). Generation of an inflammatory niche in a hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines. Science Advances, 11(15), eadr2631.
    https://www.science.org/doi/full/10.1126/sciadv.adr2631
60. Meulewaeter, S., Aernout, I., Deprez, J., Engelen, Y., De Velder, M., Franceschini, L., ... & Lentacker, I. (2024). Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria. Journal of Controlled Release, 370, 379-391.
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61. Ogawa, K., Aikawa, O., Tagami, T., Ito, T., Tahara, K., Kawakami, S., & Ozeki, T. (2024). Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying. International Journal of Pharmaceutics, 124632.
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62. Ogawa, K., Tagami, T., Miyake, S., & Ozeki, T. (2025). Choice of organic solvent affects function of mRNA-LNP; pyridine produces highly functional mRNA-LNP. International Journal of Pharmaceutics, 673, 125367.
    https://doi.org/10.1016/j.ijpharm.2025.125367
63. Owen FENTON, Yutian MA, Palas TIWADE.Compositions and methods for delivering cargo to cells. (WO2024216026A1)
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64. Owen FENTON, Yutian MA. Polyphenol lipid nanoparticles and methods of use. (WO2024107938A2)
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65. Owen Shea Fenton, Eshan Amruth NARASIPURA. Cholesterol derivatives and methods of use. (WO2025014916A1)
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66. Owen Shea Fenton, Yutian MA, Rachel VANKEULEN-MILLER. Approaches for optimization and discovery of nanoparticles and uses thereof. (WO2025178896A1)
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67. Owen Shea Fenton, Yutian MA. Vectors for nucleic acid delivery. (WO2024220665A1)
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68. Qin, Jane, Ju Hyeong Jeon, Jiangsheng Xu, Laura Katherine Langston, Ramesh Marasini, Stephanie Mou, Brian Montoya et al. Design and preclinical evaluation of a universal SARS-CoV-2 mRNA vaccine. Frontiers in Immunology. 2023
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69. Rochman, Y., Kotliar, M., Klingler, A. M., Rochman, M., Alameh, M. G., Melamed, J. R., ... & Rothenberg, M. E. (2025). Allergen-specific mRNA–lipid nanoparticle therapy for prevention and treatment of experimental allergy in mice. The Journal of Clinical Investigation, 135(21).
    https://www.jci.org/articles/view/194080
70. Ruppl, A., Kiesewetter, D., Koell-Weber, M., Lemazurier, T., Süss, R., & Allmendinger, A. (2025). Formulation screening of lyophilized mRNA-lipid nanoparticles. International Journal of Pharmaceutics, 125272.
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71. Ruppl, A., Kiesewetter, D., Strütt, F., Köll-Weber, M., Süss, R., & Allmendinger, A. (2024). Don’t shake it! Mechanical stress testing of mRNA-lipid nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics, 198, 114265.
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72. Sakers, S. H., Fiduccia, G., Byrne, K. E., Reddy, B. P. K., Dahlman, J. E., & Prausnitz, M. R. (2025). The effect of mRNA-lipid nanoparticle composition on stability during microneedle patch manufacturing. European Journal of Pharmaceutics and Biopharmaceutics, 114819.
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73. Sakers, S. H., Reddy, B. P. K., Fiduccia, G., Byrne, K. E., Stén, I., Kim, J., ... & Prausnitz, M. R. (2025). Development of a microneedle patch for delivery of mRNA-lipid nanoparticles. Drug Delivery and Translational Research, 1-16.
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74. Saraswat, A., Vemana, H. P., Dukhande, V., & Patel, K. (2024). Novel gene therapy for drug-resistant melanoma: Synergistic combination of PTEN plasmid and BRD4 PROTAC-loaded lipid nanocarriers. Molecular Therapy-Nucleic Acids, 35(3).
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75. Saraswat, Aishwarya, and Ketan Patel. Delineating effect of cationic head group and preparation method on transfection versus toxicity of lipid-based nanoparticles for gene delivery. PREPRINT. 2023
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76. Shah, N., Soma, S. R., Quaye, M. B., Mahmoud, D., Ahmed, S., Malkoochi, A., & Obaid, G. (2024). A Physiochemical, In Vitro, and In Vivo Comparative Analysis of Verteporfin–Lipid Conjugate Formulations: Solid Lipid Nanoparticles and Liposomes. ACS Applied Bio Materials.
    https://pubs.acs.org/doi/full/10.1021/acsabm.4c00316
77. Shah, S., Ranasinghe, M., Decker, J., Fraser, K., Friedman, A., Wang, Y., ... & Yao, S. (2025). Lipid Nanoparticles with Aptamers Enable Targeted mRNA Delivery to CD4⁺ T Cells. bioRxiv, 2025-09.
    https://www.biorxiv.org/content/10.1101/2025.09.10.675359v1.full
78. Shin, J. E., Won, E. J., Xu, J., Lee, J. C., Bang, J. K., Mitchell, M. J., & Cha-Molstad, H. (2025). Transition temperature-guided design of lipid nanoparticles for effective mRNA delivery. ACS Applied Materials & Interfaces, 17(19), 28012-28024.
    https://pubs.acs.org/doi/full/10.1021/acsami.5c06464
79. Shinkai, T., Ogawa, K., Tagami, T., & Ozeki, T. (2024). Cholic acid-mediated targeting of mRNA-LNPs improve the mRNA delivery to Caco-2 cells. Journal of Nanoparticle Research, 26(11), 1-12.
    https://link.springer.com/article/10.1007/s11051-024-06161-6
80. Shkodra, B., Muglikar, A., Thangapandian, J., Schumacher, M., Binici, B., & Perrie, Y. (2025). Boosting LNP performance: higher concentrations of lipid mixtures improve in vivo gene expression and storage stability. Pharmaceutics, 18(1), 50.
    https://www.mdpi.com/1999-4923/18/1/50
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BroadPharm의 모든 제품들을 만나보세요!

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