Broadpharm는 생화학 제품과 연구용 화학 시약을 제공하는 글로벌 바이오 및 제약 회사입니다.

제품 설명 

SM-102

제품 번호

BP-25499

제품 특징

ALC-0315 is a synthetic amino lipid. It is a colorless oil. ALC-0315 is one of four components that form lipid nanoparticles (LNPs) in mRNA-based COVID-19 vaccines. It encapsulates and protects the fragile mRNA which is the active ingredient in these drugs. IUPAC name: [(4-Hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate). The pKa is 6.09. Reagent grade, for research purpose.

• Catalog:

   

  BP-25498

• Name:

   

  ALC-0315

• Formula:

   

  C48H95NO5

• MW:

   

  766.3

• CAS:

   

  2036272-55-4

• Purity:

   

  98%

• Ships Within:

   

  24 Hours

• Storage Condition:

   

  -20°C

• Solubility:

   

  Ethanol, DMSO, DMF

• Shipping:

   

  Ambient Temperature

• Availability:

   

  In Stock

• NMR:

   

  View

• SDS:

   

  View

Product Citations

1. Binici, B., Rattray, Z., & Perrie, Y. (2025). A comparative study of cationic lipid-enriched LNPs for mRNA vaccine delivery. International Journal of Pharmaceutics, 125941.
   https://www.sciencedirect.com/science/article/pii/S0378517325007781
2. Boldyrev, I.A., Shendrikov, V.P., Vostrova, A.G. et al. A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix. Russ J Bioorg Chem 49, 412–415 (2023). https://doi.org/10.1134/S1068162023020061
   https://link.springer.com/article/10.1134/S1068162023020061
3. Borah, A., Giacobbo, V., Binici, B., Baillie, R., & Perrie, Y. (2025). From in vitro to in Vivo: The Dominant role of PEG-Lipids in LNP performance. European Journal of Pharmaceutics and Biopharmaceutics, 114726.
   https://doi.org/10.1016/j.ejpb.2025.114726
4. Borah, A., Giacobbo, V., Binici, B., Baillie, R., & Perrie, Y. (2025). From in vitro to in vivo: The Dominant role of PEG-Lipids in LNP performance. European Journal of Pharmaceutics and Biopharmaceutics, 114726.
   https://www.sciencedirect.com/science/article/pii/S0939641125001031
5. Casmil, I. C., Bathula, N. V., Huang, C., Wayne, C. J., Cairns, E. S., Friesen, J. J., ... & Blakney, A. K. (2025). Alphaviral backbone of self-amplifying RNA enhances protein expression and immunogenicity against SARS-CoV-2 antigen. Molecular Therapy, 33(2), 514-528.
   https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(24)00855-4
6. Casmil, I. C., Friesen, J. J., Bathula, N. V., Strumpel, A., Ho, C. H., Guez, I., ... & Blakney, A. K. (2025). Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities. Advanced Science, e08907.
   https://advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202508907
7. Chen, S. P., Wang, S., Liao, S., & Blakney, A. K. (2024). Exploring the Effects of Incorporating Different Bioactive Phospholipids into Messenger Ribonucleic Acid Lipid Nanoparticle (mRNA LNP) Formulations. ACS Bio & Med Chem Au.
   https://pubs.acs.org/doi/full/10.1021/acsbiomedchemau.4c00085
8. Coussens, E. Exploring the potential of CRISPR/Cas9 lipid nanoparticles to cure HIV.
   https://lib.ugent.be/catalog/rug01:003212736
9. De Peña, A. C., Zimmer, D., Gutterman-Johns, E., Chen, N. M., Tripathi, A., & Bailey-Hytholt, C. M. (2024). Electrophoretic Microfluidic Characterization of mRNA-and pDNA-Loaded Lipid Nanoparticles. ACS Applied Materials & Interfaces.
   https://pubs.acs.org/doi/abs/10.1021/acsami.4c00208
10. Estes, B. J., Gandhi, N., Von Stetina, J. R., Paudel, D., Nan, A. X., Amin, P., ... & Xie, J. (2025). Development of circular AAV cargos for targeted seamless insertion with large serine integrases. Molecular Therapy Methods & Clinical Development, 33(2).
    https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(25)00085-3
11. Gaisin, K. S., Ryabukhina, E. V., Koroev, D. O., Mikhalyov, I. I., Zhuravlev, E. S., Stepanov, G. A., ... & Vodovozova, E. L. (2025). An Ionizable Cationic Lipid for Intracellular RNA Delivery. Russian Journal of Bioorganic Chemistry, 51(5), 1982-1989.
    https://link.springer.com/article/10.1134/S1068162025602149
12. Grigoriev, V., Korzun, T., Moses, A. S., Jozic, A., Zhu, X., Kim, J., ... & Taratula, O. (2024). Targeting Metastasis in Head and Neck Squamous Cell Carcinoma Using Follistatin mRNA Lipid Nanoparticles. ACS nano, 18(49), 33330-33347.
    https://pubs.acs.org/doi/full/10.1021/acsnano.4c06930
13. Ho, C. H., Casmil, I. C., Sharma, M., Rees, T., Enright, K., Allan, N., & Blakney, A. K. (2025). Laminar fluid ejection device enables high yield and preservation of mRNA and SaRNA LNP formulations. Scientific Reports, 15(1), 18507.
    https://www.nature.com/articles/s41598-025-03309-9
14. https://advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202503725
    Lipid
15. https://pubs.acs.org/doi/full/10.1021/acsnano.5c15903
    Lipid
16. https://www.sciencedirect.com/science/article/pii/S0168365925009800
    Lipid
17. Hussain, M., Binici, B., O’Connor, L., & Perrie, Y. (2024). Production of mRNA lipid nanoparticles using advanced crossflow micromixing. Journal of Pharmacy and Pharmacology, 76(12), 1572-1583.
    https://academic.oup.com/jpp/article/76/12/1572/7816331
18. Hussain, M., Ferguson-Ugorenko, A., Macfarlane, R., Orr, N., Clarke, S., Wilkinson, M. J., ... & Perrie, Y. (2025). Mind the age gap: expanding the age window for mRNA vaccine testing in mice. Vaccines, 13(4), 370.
    https://www.mdpi.com/2076-393X/13/4/370
19. Janssens, S., Bosteels, V., Marechal, S., Cloots, E., Van Heddegem, L., Tavernier, S., ... & Le Goff, W. (2024). The unfolded protein sensor IRE1a is essential for homeostatic dendritic cell maturation.
    https://www.researchsquare.com/article/rs-4763670/v1
20. Janssens, S., Rennen, S., Bosteels, V., De Nolf, C., Van Lil, K., Maréchal, S., ... & Lentacker, I. (2024). Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways.
    https://doi.org/10.21203/rs.3.rs-5461735/v1
21. Kannan, R., Tran, B., Le, Q., Hohenwarter, L., Chao, P. H., Brar, V., ... & Li, S. D. (2025). Incorporation of a polyamine into lipid nanoparticles increases the endosomal release and transfection of nucleic acids without toxicity. Journal of Controlled Release, 114366.
    https://www.sciencedirect.com/science/article/pii/S0168365925009800
22. Khalifeh, M., Oude Egberink, R., Roverts, R., & Brock, R. (2025). Incorporation of ionizable lipids into the outer shell of lipid-coated calcium phosphate nanoparticles boosts cellular mRNA delivery. International Journal of Pharmaceutics, 670, 125109.
    https://www.sciencedirect.com/science/article/pii/S0378517324013437
23. Kirshina, A., Vasileva, O., Kunyk, D., Seregina, K., Muslimov, A., Ivanov, R., & Reshetnikov, V. (2023). Effects of Combinations of Untranslated-Region Sequences on Translation of mRNA. Biomolecules, 13(11), 1677.
    https://www.mdpi.com/2218-273X/13/11/1677
24. Kukushkin, I., Vasileva, O., Kunyk, D., Kolmykov, S., Sokolova, T., Muslimov, A., ... & Reshetnikov, V. (2024). Effects of Various Poly (A) Tails on Luciferase Expression. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 18(3), 263-274.
    https://link.springer.com/article/10.1134/S1990750824600055
25. Lewis, M. M., Beck, T. J., & Ghosh, D. (2023). Applying machine learning to identify ionizable lipids for nanoparticle-mediated delivery of mRNA. bioRxiv, 2023-11.
    https://doi.org/10.1101/2023.11.09.565872
26. Li, Zhongyu, Xue‐Qing Zhang, William Ho, Xin Bai, Dabbu Kumar Jaijyan, Fengqiao Li, Ranjeet Kumar et al. "Lipid‐Polymer Hybrid “Particle‐in‐Particle” Nanostructure Gene Delivery Platform Explored for Lyophilizable DNA and mRNA COVID‐19 Vaccines. Advanced Functional Materials. 2022
    https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202204462
27. Lindsay, S., Hussain, M., Binici, B., & Perrie, Y. (2025). Exploring the challenges of lipid nanoparticle development: the in vitro–in vivo correlation gap. Vaccines, 13(4), 339.
    https://www.mdpi.com/2076-393X/13/4/339
28. Mae LEWIS, Debadyuti GHOSH. Aerosolized lipid nanoparticles and uses thereof. (WO2024107702A1)
    https://patents.google.com/patent/WO2024107702A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=17
29. McMillan, C., Druschitz, A., Rumbelow, S., Borah, A., Binici, B., Rattray, Z., & Perrie, Y. (2024). Tailoring lipid nanoparticle dimensions through manufacturing processes. RSC pharmaceutics.
    https://pubs.rsc.org/en/content/articlehtml/2024/pm/d4pm00128a
30. Owen FENTON, Yutian MA. Polyphenol lipid nanoparticles and methods of use. (WO2024107938A2)
    https://patents.google.com/patent/WO2024107938A2/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=17
31. Owen Shea Fenton, Yutian MA. Vectors for nucleic acid delivery. (WO2024220665A1)
    https://patents.google.com/patent/WO2024220665A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=13
32. Park, J., Kim, B., Ha, M., Park, M., Ryu, H., Yu, H., ... & Park, H. CRISPRa Lipid Nanocomplex‐Mediated Mt3 Targeting Enhances Astrocytic Endocytosis of Amyloid‐β in an Alzheimer's Disease Mouse Model. Advanced Science, e03725.
    https://advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202503725
33. Reshetnikov, V., Terenin, I., Shepelkova, G., Yeremeev, V., Kolmykov, S., Nagornykh, M., ... & Ivanov, R. (2024). Untranslated Region Sequences and the Efficacy of mRNA Vaccines against Tuberculosis. International Journal of Molecular Sciences, 25(2), 888.
    https://www.mdpi.com/1422-0067/25/2/888
34. Rubtsova, M., Mokrushina, Y., Andreev, D., Poteshnova, M., Shepelev, N., Koryagina, M., ... & Rubtsov, Y. (2025). A Luciferase-Based Approach for Functional Screening of 5′ and 3′ Untranslated Regions of the mRNA Component for mRNA Vaccines. Vaccines, 13(5), 530.
    https://www.mdpi.com/2076-393X/13/5/530
35. Sakers, S. H., Fiduccia, G., Byrne, K. E., Reddy, B. P. K., Dahlman, J. E., & Prausnitz, M. R. (2025). The effect of mRNA-lipid nanoparticle composition on stability during microneedle patch manufacturing. European Journal of Pharmaceutics and Biopharmaceutics, 114819.
    https://www.sciencedirect.com/science/article/pii/S0939641125001961
36. Shepelkova, G. S., Reshetnikov, V. V., Avdienko, V. G., Sheverev, D. V., Yeremeev, V. V., & Ivanov, R. A. IMPACT OF UNTRANSLATED mRNA SEQUENCES ON IMMUNOGENICITY OF mRNA VACCINES AGAINST M. TUBERCULOSIS IN MICE.
    https://www.researchgate.net/profile/V-Yeremeev/publication/377479822_Impact_of_untranslated_mRNA_sequences_on_immunogenicity_of_mRNA_vaccines_against_M_tuberculosis_in_mice/links/65c1cae634bbff5ba7ef9969/Impact-of-untranslated-mRNA-sequences-on-immunogenicity-of-mRNA-vaccines-against-M-tuberculosis-in-mice.pdf
37. Shi, P., Liu, H., Refaat, A., Nguyen, H., Nguyen, A., Miao, K., ... & Wang, X. (2025). Innovative γ-Oryzanol and KC2 Based Lipid Nanoparticles: OryKL Platform Provides Safe and Efficient In Vivo mRNA Delivery.
    https://chemrxiv.org/engage/chemrxiv/article-details/68bfb8ed728bf9025e262993
38. Shyh-Dar Li, Ramya KANNAN, Quan Li, Feng Zhao, Binh Tran, Jiamin Wu, Pei Jen Angel LEE. Polymers for enhancing lipid nanoparticle delivery of nucleic acids. (WO2025207986A1)
    https://patents.google.com/patent/WO2025207986A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=1
39. VanKeulen-Miller, R., Huff, J., Narasipura, E. A., Browne, E. P., & Fenton, O. S. (2025). Customizable mRNA Lipid Nanoparticles for Transfection of Primary Human T Cells. ACS nano.
    https://pubs.acs.org/doi/full/10.1021/acsnano.5c15903
40. Wei, C., Zhu, Y., Lu, X., Goodier, K. D., Yu, D., Liu, X., ... & Mao, H. Q. (2025). Systemic trafficking of mRNA lipid nanoparticle vaccine following intramuscular injection generates potent tissue-specific T cell response. bioRxiv, 2025-04.
    https://doi.org/10.1101/2025.04.21.649878
41. Wei, C., Zhu, Y., Lu, X., Goodier, K. D., Yu, D., Liu, X., ... & Mao, H. Q. (2025). Systemic trafficking of mRNA lipid nanoparticle vaccine following intramuscular injection generates potent tissue-specific T cell response. bioRxiv, 2025-04.
    https://www.biorxiv.org/content/10.1101/2025.04.21.649878v1.full
42. Yong, S. B., Ha, M., & Cho, S. (2025). Microbiome Metabolite-Incorporated Lipid Nanoparticles Augment CD8+ T Cell Memory Potential and Immunity for mRNA Cancer Vaccines. ACS Biomaterials Science & Engineering.
    https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.5c00738
43. Zhao, F., Luppi, B., Chao, P. H., Yang, J., Zhang, Y., Feng, R., ... & Li, S. D. (2026). Biodegradable polymers with tertiary amines enhance mRNA delivery of lipid nanoparticles via improved endosomal escape. Biomaterials, 324, 123541.
    https://www.sciencedirect.com/science/article/abs/pii/S0142961225004600
44. Роман Алексеевич Иванов, Василий Владимирович Решетников, Альберт Радикович Муслимов. Multi-epitope polypeptide for immunization against mycobacterium tuberculosis. (RU2824195C1)
    https://patents.google.com/patent/RU2824195C1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=23
45. Роман Алексеевич Иванов, Василий Владимирович Решетников, Илья Михайлович Теренин. NUCLEIC ACID CONTAINING REGULATORY ELEMENTS OF RABBIT β-GLOBIN GENE, mtRNR1 AND EMCV. (RU2831165C1)
    https://patents.google.com/patent/RU2831165C1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=19
46. Роман Алексеевич Иванов, Василий Владимирович Решетников, Ольга Олеговна Васильева. Nucleic acid containing regulatory elements h4c2, aes and mtrnr1. (RU2831168C1)
    https://patents.google.com/patent/RU2831168C1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=19
47. Роман Алексеевич Иванов, Василий Владимирович Решетников, Ольга Олеговна Васильева. NUCLEIC ACID CONTAINING REGULATORY ELEMENTS OF RABBIT β-GLOBIN GENE, mtRNR1 AND AES. (RU2831164C1)
    https://patents.google.com/patent/RU2831164C1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=19
48. Роман Алексеевич Иванов, Василий Владимирович Решетников, Ольга Олеговна Васильева. NUCLEIC ACID CONTAINING REGULATORY ELEMENTS TPL, AES AND mtRNR1. (RU2831163C1)
    https://patents.google.com/patent/RU2831163C1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=19
49. 김윤경, 전해근, 정혜연, 호베트그응, 이지윤. Lipid compound and composition for delivery of active substance. (WO2024106781A1)
    https://patents.google.com/patent/WO2024106781A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=18

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