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제품 설명
Recombinant Human SLC34A2/NaPi2b Protein, N-His-SUMO
제품 번호
YHB65403
제품 특징
YHB65403
E. coli
Homo sapiens (Human)
Ser251-Asp361
25.03 kDa
Recombinant
Please contact with the lab for this information.
>90% as determined by SDS-PAGE.
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Lyophilized
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitute in sterile water for a stock solution.
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Sodium/phosphate cotransporter 2B, Na(+)-dependent phosphate cotransporter 2B, Na(+)/Pi cotransporter 2B, Sodium-dependent phosphate transport protein 2B, NaPi3b, NaPi-2b, SLC34A2, Solute carrier family 34 member 2, Sodium-phosphate transport protein 2B
Data Image
References
The Dolaflexin-based Antibody-Drug Conjugate XMT-1536 Targets the Solid Tumor Lineage Antigen SLC34A2/NaPi2b. PMID: 33722858
Immunohistochemical evaluation of epithelial ovarian carcinomas identifies three different expression patterns of the MX35 antigen, NaPi2b. PMID: 28464843
SLC34A2 promotes cancer proliferation and cell cycle progression by targeting TMPRSS3 in colorectal cancer. PMID: 34929599
Characterization of SLC34A2 as a Potential Prognostic Marker of Oncological Diseases. PMID: 34944522
SLC34A2 simultaneously promotes papillary thyroid carcinoma growth and invasion through distinct mechanisms. PMID: 32005974
SLC34A2 Gene mutation of pulmonary alveolar microlithiasis: report of four cases and review of literatures. PMID: 23164546
The SLC34A2-ROS-HIF-1-induced up-regulation of EZH2 expression promotes proliferation and chemo-resistance to apoptosis in colorectal cancer. PMID: 30038060
The role of SLC34A2 in intestinal phosphate absorption and phosphate homeostasis. PMID: 30343332
Knockdown of SLC34A2 inhibits cell proliferation, metastasis, and elevates chemosensitivity in glioma. PMID: 30592329
SLC34A2 promotes neuroblastoma cell stemness via enhancement of miR-25/Gsk3β-mediated activation of Wnt/β-catenin signaling. PMID: 30868061
Impaired phosphate transport in SLC34A2 variants in patients with pulmonary alveolar microlithiasis. PMID: 35443721
Retraction Note: Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway. PMID: 36577974
Knockdown of SLC34A2 Inhibits Hepatocellular Carcinoma Cell Proliferation and Invasion. PMID: 28281971
SLC34A2 regulates miR-25-Gsk3β signaling pathway to affect tumor progression in gastric cancer stem cell-like cells. PMID: 29178392
Eight novel variants in the SLC34A2 gene in pulmonary alveolar microlithiasis. PMID: 31831582
Constitutive depletion of Slc34a2/NaPi-IIb in rats causes perinatal mortality. PMID: 33846411
SLC34A2 Regulates the Proliferation, Migration, and Invasion of Human Osteosarcoma Cells Through PTEN/PI3K/AKT Signaling. PMID: 28777670
Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer. PMID: 35437317
SLC34A2 Up-regulation And SLC4A4 Down-regulation Correlates With Invasion, Metastasis, And The MAPK Signaling Pathway In Papillary Thyroid Carcinomas. PMID: 34405007
The effects and mechanisms of SLC34A2 in tumorigenesis and progression of human non-small cell lung cancer. PMID: 26156586
Whole-exome sequencing of non-BRCA1/BRCA2 mutation carrier cases at high-risk for hereditary breast/ovarian cancer. PMID: 33326660
Elevated expression of SLC34A2 inhibits the viability and invasion of A549 cells. PMID: 25017204
SLC34A2 as a novel marker for diagnosis and targeted therapy of breast cancer. PMID: 21036732
Overexpression of SLC34A2 is an independent prognostic indicator in bladder cancer and its depletion suppresses tumor growth via decreasing c-Myc expression and transcriptional activity. PMID: 28151475
[Pulmonary alveolar microlithiasis caused by SLC34A2 gene compound heterozygous variations in a child]. PMID: 35768363
A novel SLC34A2 mutation in a patient with pulmonary alveolar microlithiasis. PMID: 28144448
The effects and mechanisms of SLC34A2 on tumorigenicity in human non-small cell lung cancer stem cells. PMID: 26846105
Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability. PMID: 36253446
MicroRNA-410 acts as oncogene in NSCLC through downregulating SLC34A2 via activating Wnt/β-catenin pathway. PMID: 26910912
The effects and mechanisms of SLC34A2 on maintaining stem cell-like phenotypes in CD147+ breast cancer stem cells. PMID: 28381172
Evaluation of the Prognostic Value of Solute Carrier Family 34 Member 2 "SLC34A2" in Papillary Thyroid Carcinoma: An Immunohistochemical Study. PMID: 34336552
SLC34A2 gene compound heterozygous mutation identification in a patient with pulmonary alveolar microlithiasis and computational 3D protein structure prediction. PMID: 25606438
High expression of SLC34A2 is a favorable prognostic marker in lung adenocarcinoma patients. PMID: 28720066
Enhanced SLC34A2 in breast cancer stem cell-like cells induces chemotherapeutic resistance to doxorubicin via SLC34A2-Bmi1-ABCC5 signaling. PMID: 26546432
Effect of SLC34A2 gene mutation on extracellular phosphorus transport in PAM alveolar epithelial cells. PMID: 29375690
Long non-coding RNA MEG3 regulates migration and invasion of lung cancer stem cells via miR-650/SLC34A2 axis. PMID: 31585300
SLC34A2 gene mutation may explain comorbidity of pulmonary alveolar microlithiasis and aortic valve sclerosis. PMID: 22336687
Pulmonary Alveolar Microlithiasis. PMID: 27514591
Is SLC34A2 Associated With Concomitant Calcium Metabolism Disorder in Pulmonary Alveolar Microlithiasis (PAM)? PMID: 37217383
Transient DUX4 expression in human embryonic stem cells induces blastomere-like expression program that is marked by SLC34A2. PMID: 35777358
[Detection of SLC34A2 in patients with pulmonary alveolar microlithiasis and the effect of SLC34A2 on transportation of calcium and phosphate in human alveolar epithelial cells]. PMID: 19134407
Circular RNA F-circSR derived from SLC34A2-ROS1 fusion gene promotes cell migration in non-small cell lung cancer. PMID: 31118036
Quantitative analysis of SLC34A2 expression in different types of ovarian tumors. PMID: 21716206
Novel human pathological mutations. SLC34A2. Disease: pulmonary alveolar microlithiasis. PMID: 21488279
Novel deletion of SLC34A2 in Chinese patients of PAM shares mutation hot spot with fusion gene SLC34A2-ROS1 in lung cancer. PMID: 30262706
Mechanisms of phosphate transport. PMID: 31168066
Antibody-drug conjugates in gynecologic malignancies. PMID: 30929824
Intestinal Depletion of NaPi-IIb/Slc34a2 in Mice: Renal and Hormonal Adaptation. PMID: 25827490
Heterogeneity in Human Induced Pluripotent Stem Cell-derived Alveolar Epithelial Type II Cells Revealed with ABCA3/SFTPC Reporters. PMID: 34101541
Novel human pathological mutations. Gene symbol: SLC34A2. Disease: pulmonary alveolar microlithiasis. PMID: 19309776
Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway. PMID: 28114937
Pulmonary Alveolar Microlithiasis - A Review. PMID: 34970102
Association of SLC34A2 variation and sodium-lithium countertransport activity in humans and baboons. PMID: 19119262
Characterizing and evaluating the expression of the type IIb sodium-dependent phosphate cotransporter (slc34a2) gene and its potential influence on phosphorus utilization efficiency in yellow catfish (Pelteobagrus fulvidraco). PMID: 26298316
Correction to: The effects and mechanisms of SLC34A2 in tumorigenesis and progression of human non-small cell lung cancer. PMID: 30755199
Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis. PMID: 17095743
The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction. PMID: 28887454
Stimulation of the intestinal phosphate transporter SLC34A2 by the protein kinase mTOR. PMID: 16730658
Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb (SLC34A2) by the Kinases SPAK and OSR1. PMID: 26506223
A frame-shift mutation in the SLC34A2 gene in three patients with pulmonary alveolar microlithiasis in an inbred family. PMID: 20046000
Phosphate Transport in Epithelial and Nonepithelial Tissue. PMID: 32353243
Pulmonary alveolar microlithiasis. PMID: 23741096
[A novel mutation of the SLC34A2 gene in a Chinese pedigree with pulmonary alveolar microlithiasis]. PMID: 20017296
Characterization of the isoforms of type IIb sodium-dependent phosphate cotransporter (Slc34a2) in yellow catfish, Pelteobagrus fulvidraco, and their vitamin D3-regulated expression under low-phosphate conditions. PMID: 27620186
Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis. PMID: 16960801
Nuclear xenobiotic receptor PXR-null mouse exhibits hypophosphatemia and represses the Na/Pi-cotransporter SLC34A2. PMID: 19898264
Preclinical Development of an Anti-NaPi2b (SLC34A2) Antibody-Drug Conjugate as a Therapeutic for Non-Small Cell Lung and Ovarian Cancers. PMID: 26156394
Pulmonary alveolar microlithiasis. State-of-the-art review. PMID: 23183116
Response to crizotinib in a lung adenocarcinoma patient harboring a novel SLC34A2-ROS1 fusion variant. PMID: 28860822
Mechanisms and Regulation of Intestinal Phosphate Absorption. PMID: 29978897
Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas. PMID: 18251464
The sodium-phosphate co-transporter SLC34A2, and pulmonary alveolar microlithiasis: Presentation of an inbred family and a novel truncating mutation in exon 3. PMID: 26744662
Pulmonary alveolar microlithiasis: no longer in the stone age. PMID: 32964001
A case of pulmonary alveolar microlithiasis associated with a homozygous 195 kb deletion encompassing the entire SLC34A2 gene. PMID: 27099741
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