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제품 설명

PE/Cyanine7 Anti-Human CD8a Antibody[OKT-8]

제품 번호

E-AB-F1110H

제품 특징

Product Details

Background	CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
Alternate Names	CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2
Swissprot	P01732
Clone No	OKT-8
Host	Mouse
Reactivity	Human
Isotype	Mouse IgG2a, κ
Isotype Control	PE/Cyanine7 Mouse IgG2a, κ Isotype Control[C1.18.4]
Application	FCM
Form	Liquid
Conjugation	PE/Cyanine 7
Conjugation information	PE/Cyanine7 is designed to be excited by the Blue (488 nm), Green (532 nm) and yellow-green (561 nm) lasers and detected using an optical filter centered near 775 nm (e.g., a 780/60 nm bandpass filter).
Spectrum
Storage Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage	This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Expiration date	12 months
Shipping	Ice bag

Related Products

Cat.No.	Product Name	Sizes
E-AB-F11100	AF/LE Purified Anti-Human CD8a Antibody[OKT-8]	500μg , 50μg , 1mg
E-AB-F1110A	Purified Anti-Human CD8a Antibody[OKT-8]	100μg , 25μg
E-AB-F1110B	Biotin Anti-Human CD8a Antibody[OKT-8]	100μg , 25μg
E-AB-F1110C	FITC Anti-Human CD8a Antibody[OKT-8]	100Tests , 20Tests , 100Tests×2
E-AB-F1110D	PE Anti-Human CD8a Antibody[OKT-8]	100Tests , 20Tests , 100Tests×2
E-AB-F1110E	APC Anti-Human CD8a Antibody[OKT-8]	100Tests , 20Tests , 100Tests×2
E-AB-F1110F	PerCP Anti-Human CD8a Antibody[OKT-8]	100Tests , 20Tests , 100Tests×2
E-AB-F1110G	PE/Cyanine5 Anti-Human CD8a Antibody[OKT-8]	100Tests , 20Tests , 100Tests×2
E-AB-F1110I	PE/Cyanine5.5 Anti-Human CD8a Antibody[OKT-8]	100Tests , 20Tests , 100Tests×2
E-AB-F1110J	PerCP/Cyanine5.5 Anti-Human CD8a Antibody[OKT-8]	100Tests , 20Tests , 100Tests×2
E-AB-F1110L	Elab Fluor® 488 Anti-Human CD8a Antibody[OKT-8]	100Tests , 20Tests , 100Tests×2
E-AB-F1110M	Elab Fluor® 647 Anti-Human CD8a Antibody[OKT-8]	100Tests , 20Tests , 100Tests×2
E-AB-F1110Q	Elab Fluor® Violet 450 Anti-Human CD8a Antibody[OKT-8]	100Tests , 20Tests , 100Tests×2
E-AB-F1110S	Elab Fluor® Red 780 Anti-Human CD8a Antibody[OKT-8]	100Tests , 20Tests , 100Tests×2

FAQ

Q1:In flow cytometry experiment, is it possible to detecet cytokine without stimulation?
Usually, it is difficult to do so. It might be able to detect the biomarker in some treatment group, but the concentration will be lower than the detection limit in more groups.
Q2:Are CD8 and CD8α the same index?
Yes they are. CD8 and CD8α are widely used markers for identifying cytotoxic T lymphocytes (CTLs). CD8 plays an important role in mediating the recognition and excution funtions of CTLs. CD8α is a subunit of CD8 complex, which means the α chain, and it is quite important in the formation of the complex. CD8α chain not only participates in the binding with MHC-I molecules, but also regulates the activity of CTLs by interacting with other signal molecules. Therefore, the expression level and functional status of CD8α can be used for evaluating the activation and effection of CTLs, as well as CD8.

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