Proteogenix는 Primary Antibody Biosimilar - Research Grade
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제품 설명
제품 번호
PX-P5960
제품 특징
Product name | TNFa / TNF-alpha, N-His, recombinant protein (E.coli) |
---|---|
Origin species | Homo sapiens (Human) |
Expression system | Prokaryotic expression |
Molecular weight | 19.66 kDa |
Protein delivered with Tag? | N-terminal His Tag |
Purity estimated | >90% as determined by SDS-PAGE |
Buffer | PBS, pH7.5 |
Delivery condition | Dry Ice |
Storage condition | 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection) |
Brand | ProteoGenix |
Host species | Escherichia coli (E.coli) |
Applications | ELISA,WB |
Fragment Type | Val77-Leu233 |
Protein Accession | P01375 |
Aliases /Synonyms | cachexin, cachectin |
Reference | PX-P5960 |
Note | For research use only |
TNF-alpha (tumor necrosis factor-alpha) is a cytokine protein produced by various cells in the body. It is a type of pro-inflammatory cytokine, meaning it plays an important role in the body’s immune response.
TNF-alpha is a homotrimeric glycoprotein composed of three identical subunits, each around 17 kDa in size. Each subunit is composed of an N-terminal signal peptide, a pro-region, and a mature region.
TNF-alpha is involved in a variety of cellular processes, including cell differentiation, apoptosis, and the regulation of immune responses. It binds to two distinct receptors, TNFR1 and TNFR2, and activates a variety of intracellular signaling pathways.
TNF-alpha is a key mediator of inflammation, and has been implicated in a variety of diseases, including rheumatoid arthritis, psoriasis, and Crohn’s disease. As such, it has become a major target for therapeutic intervention. A number of TNF-alpha inhibitors have been developed for the treatment of these conditions.
QC & Validation Data
TNFa / TNF-alpha, N-His, recombinant protein on SDS-PAGE under reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is superior than 90 %.
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