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Proteogenix

[Proteogenix] TNFa / TNF-alpha, N-His, recombinant protein (E.coli)

Cat-No. PX-P5960


Proteogenix는 Primary Antibody Biosimilar - Research Grade 

제품을 전문적으로 생산하는 20년의 경험이 있는 High Quality 제조사입니다.




제품 설명 


TNFa / TNF-alpha, N-His, recombinant protein (E.coli)

 



제품 번호

 

PX-P5960

 



제품 특징


Product nameTNFa / TNF-alpha, N-His, recombinant protein (E.coli)
Origin speciesHomo sapiens (Human)
Expression systemProkaryotic expression
Molecular weight19.66 kDa
Protein delivered with Tag?N-terminal His Tag
Purity estimated>90% as determined by SDS-PAGE
BufferPBS, pH7.5
Delivery conditionDry Ice
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesEscherichia coli (E.coli)
ApplicationsELISA,WB
Fragment TypeVal77-Leu233
Protein AccessionP01375
Aliases /Synonymscachexin, cachectin
ReferencePX-P5960
NoteFor research use only


Description of TNFa / TNF-alpha, N-His, recombinant protein (E.coli)

General information on TNFa / TNF-alpha, N-His, recombinant protein

TNF-alpha: Structure, Activity, and Application

TNF-alpha (tumor necrosis factor-alpha) is a cytokine protein produced by various cells in the body. It is a type of pro-inflammatory cytokine, meaning it plays an important role in the body’s immune response.

Structure

TNF-alpha is a homotrimeric glycoprotein composed of three identical subunits, each around 17 kDa in size. Each subunit is composed of an N-terminal signal peptide, a pro-region, and a mature region.

Activity

TNF-alpha is involved in a variety of cellular processes, including cell differentiation, apoptosis, and the regulation of immune responses. It binds to two distinct receptors, TNFR1 and TNFR2, and activates a variety of intracellular signaling pathways.

Application

TNF-alpha is a key mediator of inflammation, and has been implicated in a variety of diseases, including rheumatoid arthritis, psoriasis, and Crohn’s disease. As such, it has become a major target for therapeutic intervention. A number of TNF-alpha inhibitors have been developed for the treatment of these conditions.




QC & Validation Data


SDS-PAGE for TNFa / TNF-alpha, N-His, recombinant protein

TNFa / TNF-alpha, N-His, recombinant protein on SDS-PAGE under reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is superior than 90 %.




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