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제품 설명

Aggrecan IGD Antibody, 100 ug

제품 번호

1042005

제품 특징

Description

Aggrecan IGD monoclonal antibody (mouse, clone 6B4). This antibody detects aggrecan metabolites (intact or matrix protease-catabolised) in human synovial fluid samples.

Proteoglycans are categorized depending upon the nature of their glycosaminoglycan chains (chondroitin sulfate, dermatan sulfate, heparan sulphate and keratan sulfate) as well as characterized by size.

Aggrecan is a large aggregating proteoglycan of articular cartilage. It is also found in aorta tissue, discs, tendons and in the perineuronal net. It is responsible for hydrating cartilage, giving it compressibility and resilience during joint loading, thereby playing a major role in the normal function of cartilage. Depletion of glycosaminoglycan-bearing aggrecan fragments is one of the earliest events in cartilage destruction.

Specifications:

• Immunogen: Synthetic peptide: EPEEPFTFAPEI
• Clone: 6B4
• Host: Mouse
• Myeloma: x63-Ag8.653
• Isotype: IgG1
• Light Chain type: kappa
• Specificity: Recognizes the linear amino acid sequence 394EPEEPFTFAPEI406 present in the interglobular domain (IGD) of human and bovine aggrecan.
• Cross-reactivity: This antibody cross-reacts with human and bovine
• Purity: Affinity purified on protein G
• Form: Liquid, 1 mL/vial
• Concentration: 0.1 mg/mL