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Hytest

[Hytest] D-dimer human, antibody

Cat-No. 4D30



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제품 설명


D-dimer human, antibody



제품 번호


4D30

 


제품 특징


  • Cat.#

    4D30

  • MAbs in vitro:

    DD3cc, DD6cc, DD41cc, DD44cc, DD46cc, DD189cc, DD255cc

    Mouse monoclonal antibody produced in bioreactor. Hybridoma clone derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice.

  • MAbs in vivo:

    DD1, DD2, DD4, DD5, DD22, DD93

    Mouse monoclonal antibody produced in ascites. Hybridoma clone derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice.

  • Immunogens:

    D-dimer for DD1, DD189cc, DD2, DD255cc, DD3cc, DD4, DD5, DD6cc

    Mixture of D-dimer and high molecular weight fibrin degradation products for DD22, DD41cc, DD44cc, DD46cc

    Synthetic peptides covering the cross-linked region of D-dimer gamma-chain for DD93

  • Specificity:

    D-dimer and high molecular weight fibrin degradation products, cross-reactivity with fibrinogen for DD4, DD5, DD6cc.

    D-dimer and high molecular weight fibrin degradation products, no cross-reactivity with fibrinogen for DD1, DD189cc, DD2, DD22, DD255cc, DD3cc, DD41cc, DD44cc, DD46cc.

    D-dimer, high molecular weight fibrin degradation products and a cross-linked region of D-dimer, no cross-reactivity with fibrinogen for DD93.

  • MAb isotypes:

    IgG1 for DD93, DD189cc, DD255cc
    IgG2a for DD1, DD6cc, DD22, DD41cc, DD46cc
    IgG2b for DD2, DD3cc, DD4, DD5, DD44cc

  • Applications:

    Immunoassays for the quantitative determination of D-dimer and high molecular weight fibrin degradation products. MAbs recognize D-dimer in ELISA.

     

    *Due to the cross-reactivity of DD4 with fibrinogen, we strongly recommend using it as the detection antibody. In a sandwich immunoassay, plasma must be diluted at least two-fold with 10 mM Tris-HCl, pH 7.5, 1 M NaCl, 0.1 % Tween 20 to avoid nonspecific binding. Each step in the assay should be followed by an incubation and wash: coating with the capture MAb, addition of the sample and addition of the (conjugated) detection MAb.
    MAbs recognize D-dimer in Western blotting under non-reducing conditions.
    DD22, DD41cc, DD44cc, DD46cc and DD189cc interact with beta-chain of D-dimer in Western blotting under reducing conditions.
    DD93 and DD255cc interact with gamma-chain of D-dimer in Western blotting under reducing conditions.

     

  • Purification:

    Protein A chromatography

  • Presentation:

    PBS, pH 7.4, 0.09 % sodium azide (NaN₃)

  • Storage:

    +4 °C (+2 … +8 °C allowed)

  • Material safety note:

    This product is sold for research or further manufacturing use only. Standard Laboratory Practices should be followed when handling this material.

    Product contains sodium azide as a preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.



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