MMAE Antibody (69F7), mAb, Mouse

제품 번호

A02224-40

제품 특징

Overview

Specificity	The product is specific for MMAE and MMAE structurally similar molecules.
Host Species	Mouse
Immunogen	MMAE-KLH
Conjugate	Unconjugated

Applications

Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.

Application	Recommended Usage
ELISA	0.5-2 µg/ml
Sandwich ELISA	0.5-2 µg/ml
Competitive ELISA	0.5-2 µg/ml

Properties

Form	Liquid
Storage Buffer	Supplied in PBS, pH 7.4, containing 0.02% ProClin300.
Concentration	0.5 mg/mL
Storage Instructions	The product remains stable for 1 year at -20℃ from the date of receipt. Avoid repeated freezing and thawing cycles.
Purification	Protein A affinity column
Isotype	Mouse IgG1, κ
Clonality	Monoclonal
Clone ID	69F7F8
Note	GenScript can customize this product per customer's request including product size, buffer components, etc.

Background

Target Background

Payloads are the important components of antibody-drug conjugates (ADCs). The most commonly used ADC payloads are MMAE, MMAF, DM1, and DXd. ADC pharmacokinetic (PK) studies include free payload analysis, conjugated antibody analysis, and total antibody analysis via ligand-binding assay (LBA) and LC-MS/MS assay. The anti-payload antibody is a useful reagent in PK assay for determining conjugated antibodies. It can be used as a capture antibody to determine the conjugated antibody in LBA assay or through immunocapture to enrich the ADC sample in LC-MS/MS assay. Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Due to its high toxicity, it cannot be administered as a standalone medication. Instead, it is conjugated with a monoclonal antibody (MAB) to specifically target cancer cells.

Synonyms

MMAE; Monomethyl auristatin E; Monomethylauristatin E; Monomethylauristatin norephedrine; Toxin MMAE; MMAE toxin

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.

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Genscript

[Genscript] MMAE Antibody (69F7), mAb, Mouse

Cat-No. A02224-40

MMAE Antibody (69F7), mAb, Mouse