Proteogenix는 Primary Antibody Biosimilar - Research Grade
제품을 전문적으로 생산하는 20년의 경험이 있는 High Quality 제조사입니다.
제품 설명
제품 번호
PX-P4557
제품 특징
Product name | IL2 Protein - Interleukin-2 Protein (IL2) |
|---|---|
| Uniprot ID | P60568 |
| Uniprot link | https://www.uniprot.org/uniprot/P60568 |
| Origin species | Homo sapiens (Human) |
| Expression system | Prokaryotic expression |
| Sequence | APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT |
| Molecular weight | 12-14kDa |
| Protein delivered with Tag? | C-terminal His Tag |
| Purity estimated | >95% by SDS-PAGE |
| Buffer | PBS pH 7.5 |
| Delivery condition | Dry Ice |
| Delivery lead time in business days | 3-5 days if in stock; 3-5 weeks if production needed |
| Storage condition | 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection) |
| Brand | ProteoGenix |
| Host species | Escherichia coli (E.coli) |
| Fragment Type | Ala21-Thr153 |
| Protein Accession | P60568 |
| Spec:Entrez GeneID | 3558 |
| Spec:NCBI Gene Aliases | IL-2; TCGF; lymphokine |
| Spec:SwissProtID | P01585 |
| NCBI Reference | P60568 |
| Aliases /Synonyms | T-cell Growth Factor proteins、TCGF、INN: Aldesleukin |
| Reference | PX-P4557 |
| Note | For research use only. |
IL2 protein also known as Interleukin-2 is a type of cytokine signaling molecule. It is involved in immune system signaling. IL2 protein are produced by T-cells. It binds to IL2 receptors expressed by lymphocytes more precisely CD4+ T cells and CD8+ T cells and can stimulate monocytes, natural killer cells, monocytes and glioma cells. This protein is important in T and B lymphocyte proliferation.
IL2 protein is involved in 3 different signaling pathways, JAK-STAT, PI3K/Akt/mTOR and MAPK/ERK pathway. IL2 protein binds to its receptor which causes the dimerization of CD122 and CD132 . This step is key for the activation of Janus kinases, more specifically JAK1 and JAK3. Janus kinase are a type of tyrosine kinases that transduce cytokine signals. The activation of JAK1 and JAK3 results in the activation of T338 on CD122 which is essential for the dimerization of STAT transcription factors. In this case it is mainly STAT5 proteins. The dimerized form of STAT migrates to the cell nucleus where it binds to the DNA.
IL2 gene expression is regulated, among others, by T-cell receptor (TCR) signaling. The latter is a molecule located on the T cell membrane and is responsible for antigen recognition. TCR signaling pathway involves phospholipase-C dependent cascade. The latter results in the activation of three different transcription factors and their respective pathways. These major transcription factors are NFAT, AP-1 and NFkB. All the members of NFAT family of proteins are located in the cytoplasm. NFAT proteins migrate to nucleus upon dephosphorylation. AP-1 is a dimer complex that cooperates with other transcription factors such as Oct and NFkB. The latter is a heterodimer and contains two binding sites for IL2 promoter. NFkB protein complex is costimulated by CD28 which is a protein expressed also on T cells and is involved in T cell activation and survival.
Publications
Kervevan J, Staropoli I, Slama D, Jeger-Madiot R, Donnadieu F, Planas D, Pietri M-P, Loghmari-Bouchneb W, Alaba Tanah M, Robinot R, Boufassa F, White M, Salmon-Ceron D and Chakrabarti LA (2023) Divergent adaptive immune responses define two types of long COVID. Front. Immunol. 14:1221961. doi: 10.3389/fimmu.2023.1221961
ProteoGenix의 모든 제품들을 만나보세요!
Proteogenix - Exclusive Distributor in South Korea "Morebio" 한국 독점 대리점 "모아바이오"
MSDS
온라인 견적
