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YEASEN

[YEASEN] Recombinant Human/Mouse/Rat BMP-2 Protein

Cat-No. 92051ES

YEASEN은 생명과학 연구 및 진단을 위한 고품질의 연구용 시약과 기기를 제공하는 글로벌 바이오 기업입니다.

제품 설명

Recombinant Human/Mouse/Rat BMP-2 Protein

제품 번호

92051ES

제품 설명

Description

Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup, where BMP2-7 belongs to TGF- β Superfamily. It plays a dominant role in embryonic dorsal ventral pattern, organogenesis, limb bud formation, and bone formation and regeneration. Mature human BMP-2 exhibits 100% aa sequence identity with mouse and rat BMP-2. It has 85% sequence identity with human BMP-4 and less than 51% sequence identity with other BMPs. Normal bone formation is a carefully regulated long-term process that involves the continuous expression of growth regulatory factors by osteoblasts during proliferation and final differentiation. Due to the ordered sequence of gene expression in osteoblasts indicating cascading effects, BMP-2 can initiate and maintain this effect. BMP-2 also promotes the maintenance and repair of colonic epithelium, inhibits the synthesis and release of dopamine in neurons, induces apoptosis in medulloblastoma cells, and is essential for myocardial contractility.

Product Properties

Synonyms	BDA2, BMP2, BMP-2, BMP-2A, SSFSC
Uniprot No.	P12643
GeneID	650
Source	E.coli-derived human BMP-2, Gln283-Arg396, with an N-terminal Met.
Molecular Weight	Approximately 26.0 kDa.
Tag	None
Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Purity	>95 % by SDS-PAGE and HPLC analyses.
Biological Activity	The ED₅₀ as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 200 ng/mL, corresponding to a specific activity of > 5.0 × 10³ IU/mg. Fully biologically active when compared to standard.
Endotoxin	< 1.0 EU per 1μg of the protein by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered concentrated solution in 10 mM sodium citrate, pH 3.5.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.

Shipping and Storage

The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.

Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.

Cautions

1. Avoid repeated freeze-thaw cycles.
2. For your safety and health, please wear lab coats and disposable gloves for operation.
3. For research use only.

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