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제품 설명
Recombinant Rat Cytokine-induced Neutrophil Chemoattractant 3/CXCL2 (Rat CINC-3/CXCL2)
제품 번호
90935ES
제품 설명
Rat CXCL2, also named CINC-3, is belonging to the CXC chemokine family. The protein sequence of mouse CXCL2 shows approximately 63% identity to that of mouse KC, another mouse alpha chemokine whose expression is induced by PDGF. The amino acid sequence of mouse CXCL2 is 60 % identical to human CXCL2. This chemokine is secreted from a mouse macrophage cell line. The functional receptor for CXCL2 has been identified as CXCR2. CXCL2 is a part of chemokine superfamily, which encodes secretory proteins involved in immune regulation and inflammation. CXCL2, a critical chemokine for neutrophils, has been shown to be produced in the rat intestine in response to platelet-activating factor (PAF) and to mediate intestinal inflammation and injury.
Synonyms | chemokine (C-X-C motif) ligand 2, CINC-2a, CINC3, C-X-C Motif Chemokine 2, CXCL2, GRO beta, GRO2, GROB, Growth-regulated protein beta, Macrophage inflammatory protein 2-alpha, MGSA beta, MGSA-beta, MIP2, SCYB2 |
Accession | |
GeneID | |
Source | E.coli-derived rat CINC-3/CXCL2 protein, Val28-Asn100. |
Molecular Weight | Approximately 7.9 kDa. |
AA Sequence | VVVASELRCQ CLTTLPRVDF KNIQSLTVTP PGPHCAQTEV IATLKDGHEV CLNPEAPLVQ RIVQKILNKG KAN |
Tag | None |
Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
Purity | >98% by SDS-PAGE and HPLC analyses. |
Biological Activity | The biological activity determined by a chemotaxis bioassay using rat neutrophils is in a concentration range of 10-100 ng/ml. Fully biologically active when compared to standard. |
Endotoxin | < 1.0 EU per 1μg of the protein by the LAL method. |
Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. |
Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
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