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제품 설명
Recombinant Rat gamma-Interferon Inducible Protein 10/CXCL10 (Rat IP-10/CXCL10)
제품 번호
90940ES
제품 설명
C–X–C motif chemokine 10 (CXCL10) also known as interferon γ-induced protein 10kDa (IP-10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family. The rhesus macaque IP-10 shares 69 %, 95 %, 74 % a.a. sequence identity with human, mouse, rat IP-10. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. CXCL10 has been shown to be a chemoattractant for activated Tlymphocytes. CXCL10 has been reported to be a potent inhibitor of angiogenesis and to display a potent thymus-dependent antitumor effect. CXCL10 is also recognized as a biomarker that predicts severity of various diseases.
Synonyms | Gamma-IP10, Small-inducible Cytokine B10, Protein Mob-1 |
Accession | |
GeneID | |
Source | E.coli-derived rat IP-10/CXCL10 protein, Ile22-Pro98. |
Molecular Weight | Approximately 8.7 kDa. |
AA Sequence | IPLARTVRCT CIDFHEQPLR PRAIGKLEII PASLSCPHVE IIATMKKNNE KRCLNPESEA IKSLLKAVSQ RRSKRAP |
Tag | None |
Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
Purity | >95% by SDS-PAGE and HPLC analyses. |
Biological Activity | The biological activity determined by a chemotaxis bioassay using human CXCR3 transfected HEK293 cells is in a concentration range of 10-50 ng/ml. Fully biologically active when compared to standard. |
Endotoxin | < 1.0 EU per 1μg of the protein by the LAL method. |
Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. |
Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
2. For your safety and health, please wear lab coats and disposable gloves for operation.
3. For research use only!
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