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제품 설명
PSME1 Recombinant Monoclonal Antibody
제품 번호
CSB-RA943230A0HU
제품 특징
Product Details
Alternative Names
Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha), PSME1, IFI5111
Immunogen
A synthesized peptide derived from human PSME1
Immunogen Species
Homo sapiens (Human)
Purification Method
Affinity-chromatography
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA, WB, IHC, IF, FC
Recommended Dilution
| Application | Recommended Dilution |
|---|
| WB | 1:500-1:2000 |
| IHC | 1:50-1:200 |
| IF | 1:50-1:200 |
| FC | 1:50-1:200 |
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description
Generating the PSME1 recombinant monoclonal antibody involves a series of intricate processes. It starts with harvesting the PSME1 monoclonal antibody and sequencing its gene. A vector carrying the PSME1 monoclonal antibody gene is then constructed and introduced into a host cell line for culture. During PSME1 monoclonal antibody production, a synthesized peptide based on human PSME1 is utilized as the immunogen. The PSME1 recombinant monoclonal antibody is subsequently purified using affinity chromatography from the cell culture supernatant and subjected to ELISA, WB, IHC, IF, and FC appli...Read more
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Related Products
PSME1 Antibodies
PSME1 Proteins
PSME1 ELISA kits
Customer Reviews and Q&A
■ Customer Reviews
Target Background
Function
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Gene References into Functions
- Such a modulation of proteasome activity is explained, at least in part, by the circadian expression of both Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and the proteasome activator PA28ab PMID: 26944190
- Results show that PA28alpha was found to be overexpressed in oral squamous cell carcinoma cell lines and tumor tissues. High expression of PA28alpha was significantly associated with recurrence and poorer overall survival. PMID: 26892607
- Constitutive expression of PA28 and ERAP1 in melanoma cells indicate that both interfere with MART-1(26-35) epitope generation even in the absence of IFN-gamma PMID: 26399368
- PA28 is a tumor marker and a potential target for therapeutic intervention in prostate cancer. PMID: 23918357
- Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNbeta in mouse pancreatic beta-cells. PMID: 23383295
- the first evidence of a novel ovarian cancer-specific marker PMID: 22532226
- PA28 selectively up-regulates the presentation of viral MHC class I epitopes and that down regulation PA28 in tumor cells results in impaired presentation of a human TRP2 tumor antigen. PMID: 12200048
- The relationship between anti-PA28alpha and Ki antibodies suggests the importance of an antigen-driven system in the induction of an autoimmune response to PA28 complex. PMID: 14760793
- DJ-1 and PA28alpha may have roles in the onset of hepatocarcinogenesis PMID: 17671684
- the 11S proteasome activator complex, Reg alpha fragment, may have a role in ovarian cancer PMID: 17939699
- bortezomib-adapted HL-60 cells showed increased expression and proteasome association of the 11S proteasome activator PMID: 19225532
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Protein Families
PA28 family
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